Unique methods and bio-imaging systems are introduced herein for self-automated self-operable biomedical devices and methods for bio-signal monitoring, such as electrocardiograms (ECG), heart rate, and other vital signs, requiring no trained medical assistance or minimal assistance. In particular, methods and devices disclosed herein may require no dedicated medical resources, generate diagnostic quality results, and provide for motion artifact correction without inducing discomfort or irritation. Moreover, long term recording is realizable. Such methods and devices reduce the backlog of patients at out-patient wards as well as emergency response in remote areas.