- 专利标题: Method of decreasing protein-aldehyde adducts by administering a mixed disulfide of n-acetylcysteine and propyl mercaptan, propenyl mercaptan, or allyl mercaptan
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申请号: US16186077申请日: 2018-11-09
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公开(公告)号: US10758498B2公开(公告)日: 2020-09-01
- 发明人: David Michael Ott
- 申请人: David Michael Ott
- 主分类号: A61K31/10
- IPC分类号: A61K31/10 ; C07C323/59 ; C07C319/24 ; A23L33/10 ; A61K31/198 ; A61K47/54 ; A61K9/48 ; A61K33/06
摘要:
Divalent salts of S-allylmercapto-N-acetylcysteine and related compositions are disclosed which can be administered in order to provide protection from the formation of aldehyde-protein adducts, protein carbonylation, protein aggregation, and the resulting neuroinflammation. Various neurodegenerative diseases which are suitable for treatment using these compositions include Alzheimer's disease, senile dementia, Parkinson's disease, multiple sclerosis, Lewy body disease, peripheral neuropathy, spinal cord injury, stroke and cerebral ischemia.
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