Invention Grant
- Patent Title: Monofunctional intermediates for ligand-dependent target protein degradation
-
Application No.: US16091544Application Date: 2017-04-06
-
Publication No.: US10759808B2Publication Date: 2020-09-01
- Inventor: Shaomeng Wang , Yangbing Li , Angelo Aguilar , Bing Zhou , Jiantao Hu , Fuming Xu , Chong Qin , Yang Hu , Weiguo Xiang , Rohan Rej , Jiuling Yang , Xin Han , Longchuan Bai , Chao-Yie Yang
- Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
- Applicant Address: US MI Ann Arbor
- Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
- Current Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
- Current Assignee Address: US MI Ann Arbor
- Agency: Marshall, Gerstein & Borun LLP
- International Application: PCT/US2017/026275 WO 20170406
- International Announcement: WO2017/176958 WO 20171012
- Main IPC: C07D401/04
- IPC: C07D401/04 ; C07D487/10 ; C07D401/14 ; C07D487/04 ; C07D495/14
Abstract:
The present disclosure provides compounds represented by Formula I: and the salts or solvates thereof, wherein X, L, Y, and B are as defined in the specification. Compounds having Formula I are immunomodulators and/or monofunctional synthetic intermediates that can be used to prepare small-molecule drug conjugates.
Public/Granted literature
- US20190119289A1 MONOFUNCTIONAL INTERMEDIATES FOR LIGAND-DEPENDENT TARGET PROTEIN DEGRADATION Public/Granted day:2019-04-25
Information query
