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公开(公告)号：US20230357249A1
公开(公告)日：2023-11-09
申请号：US17924242
申请日：2021-05-14
发明人： Shaomeng Wang , Xin Han , Weiguo Xiang , Chong Qin , Tianfeng Xu , Lijie Zhao , Mingliang Wang , Rohan Rej
IPC分类号： C07D487/04 , C07D519/00
CPC分类号： C07D487/04 , C07D519/00
摘要： The present disclosure provides compounds represented by Formula I : A-L-B 1 I, and the salts or solvates thereof, wherein A, L, and B1 are as defined in the specification, ompounds having Formula I are androgen receptor degraders useful for the treatment of ancer and other diseases.
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公开(公告)号：US20220380368A1
公开(公告)日：2022-12-01
申请号：US17760786
申请日：2020-09-18
发明人： Shaomeng Wang , Xin Han , Weiguo Xiang , Bukeyan Miao , Chong Qin , Lijie Zhao , Jianfeng Lu , Tianfeng Xu , Chao-Yie Yang
IPC分类号： C07D471/10 , A61P35/00 , A61P13/08
摘要： The present disclosure provides compounds represented by Formula (I) and the salts or solvates thereof, wherein R3a, E, L, A1, B1, X1, X2, Z1, and Z2 are as defined in the specification. Compounds having Formula (I) are androgen receptor degraders useful for the treatment of cancer and other diseases.
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公开(公告)号：US20220081435A1
公开(公告)日：2022-03-17
申请号：US17420421
申请日：2019-12-19
发明人： Shaomeng Wang , Xin Han , Chao Wang , Chong Qin , Weiguo Xiang , Tianfeng Xu , Chao-Yie Yang
IPC分类号： C07D417/14 , A61K47/55 , A61K45/06
摘要： The present disclosure provides compounds represented by Formula (I): A-L-B (I), and the salts or solvates thereof, wherein A, L, and B are as defined in the specification. Compounds having Formula (I) are androgen receptor degraders useful for the treatment of cancer.
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公开(公告)号：US20190119289A1
公开(公告)日：2019-04-25
申请号：US16091544
申请日：2017-04-06
发明人： Shaomeng Wang , Yangbing Li , Angelo Aguilar , Bing Zhou , Jiantao Hu , Fuming Xu , Chong Qin , Yang Hu , Weiguo Xiang , Rohan Rej , Jiuling Yang , Xin Han , Longchuan Bai , Chao-Yie Yang
IPC分类号： C07D487/10 , C07D401/04 , C07D401/14 , C07D495/14 , C07D487/04
摘要： The present disclosure provides compounds represented by Formula I: and the salts or solvates thereof, wherein X, L, Y, and B are as defined in the specification. Compounds having Formula I are immunomodulators and/or monofunctional synthetic intermediates that can be used to prepare small-molecule drug conjugates.
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公开(公告)号：US20230257365A1
公开(公告)日：2023-08-17
申请号：US18012369
申请日：2021-07-09
发明人： Shaomeng Wang , Xin Han , Weiguo Xiang , Chong Qin , Tianfeng Xu , Lijie Zhao
IPC分类号： C07D401/14 , C07D451/06 , C07D451/14 , C07D519/00 , C07D487/04 , C07D487/10 , C07D471/04 , C07D491/08
CPC分类号： C07D401/14 , C07D451/06 , C07D451/14 , C07D519/00 , C07D487/04 , C07D487/10 , C07D471/04 , C07D491/08
摘要： The present disclosure provides compounds represented by Formula I: A-L-B1 I, and the salts or solvates thereof, wherein A, L, and B1 are as defined in the specification. Compounds having Formula I are androgen receptor degraders useful for the treatment of cancer and other diseases.
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公开(公告)号：US20230233690A1
公开(公告)日：2023-07-27
申请号：US18012267
申请日：2021-07-09
发明人： Shaomeng Wang , Xin Han , Weiguo Xiang , Chong Qin , Lijie Zhao
CPC分类号： A61K47/55 , A61K47/545
摘要： The present disclosure provides compounds represented by Formula I: A-L-B1 and the salts or solvates thereof, wherein A, L, and B1 are as defined in the specification. Compounds having Formula I are androgen receptor degraders useful for the treatment of cancer and other diseases.
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公开(公告)号：US10759808B2
公开(公告)日：2020-09-01
申请号：US16091544
申请日：2017-04-06
发明人： Shaomeng Wang , Yangbing Li , Angelo Aguilar , Bing Zhou , Jiantao Hu , Fuming Xu , Chong Qin , Yang Hu , Weiguo Xiang , Rohan Rej , Jiuling Yang , Xin Han , Longchuan Bai , Chao-Yie Yang
IPC分类号： C07D401/04 , C07D487/10 , C07D401/14 , C07D487/04 , C07D495/14
摘要： The present disclosure provides compounds represented by Formula I: and the salts or solvates thereof, wherein X, L, Y, and B are as defined in the specification. Compounds having Formula I are immunomodulators and/or monofunctional synthetic intermediates that can be used to prepare small-molecule drug conjugates.
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公开(公告)号：US11548899B2
公开(公告)日：2023-01-10
申请号：US16077844
申请日：2017-02-15
发明人： Shaomeng Wang , Bing Zhou , Yang Hu , Chao-Yie Yang , Chong Qin
IPC分类号： C07D495/14 , C07D498/14 , C07D498/04 , A61K45/06 , A61P35/04
摘要： The present disclosure provides fused 1,4-oxazepines and related analogs represented by Formula (I) and the pharmaceutically acceptable salts, hydrates, and solvates thereof, wherein R1, R2a, R2b, R3a, R3b, R4, R5, A, and Y are as defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula (I) to treat a condition or disorder responsive to inhibition of BET bromodomains such as cancer.
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公开(公告)号：US11466028B2
公开(公告)日：2022-10-11
申请号：US16332533
申请日：2017-09-13
发明人： Shaomeng Wang , Yang Hu , Chong Qin , Fuming Xu , Jiantao Hu , Bing Zhou , Zhuo Chen , Ester Fernandez-Salas , Longchuan Bai , Donna McEachern
IPC分类号： C07D498/14 , A61P35/02 , A61P35/04
摘要： The present disclosure provides compounds represented by Formula I and the pharmaceutically acceptable salts, hydrates, and solvates thereof, wherein R1, R2a, R2b, R3a, R3b, R4, Ar, L, X, Y, and B are as defined as set forth in the specification. The present disclosure also provides compounds of Formula I for use to treat a condition or disorder responsive to degradation of BET bromodomains such as cancer.
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公开(公告)号：US20210284657A1
公开(公告)日：2021-09-16
申请号：US16332533
申请日：2017-09-13
发明人： Shaomeng Wang , Yang Hu , Chong Qin , Fuming Xu , Jiantao Hu , Bing Zhou , Zhuo Chen , Ester Fernandez-Salas , Longchuan Bai , Donna McEachern
IPC分类号： C07D498/14 , A61P35/04 , A61P35/02
摘要： The present disclosure provides compounds represented by Formula I and the pharmaceutically acceptable salts, hydrates, and solvates thereof, wherein R1, R2a, R2b, R3a, R3b, R4, Ar, L, X, Y, and B are as defined as set forth in the specification. The present disclosure also provides compounds of Formula I for use to treat a condition or disorder responsive to degradation of BET bromodomains such as cancer.
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