A method of operating a multiple-compressor refrigeration system is provided. This method includes the steps of supplying, via a common supply line, refrigerant gas and oil to a plurality of compressors coupled in series, and attaching an oil flow conduit between adjacent compressors of the plurality of compressors. The oil flow conduit is configured to move oil from a compressor with a relatively higher pressure to a compressor with a relatively lower pressure. The method further includes controlling the pressure for each of the plurality of compressors by regulating a speed at which each of the plurality of compressors operates in order to maintain a pressure differential between the adjacent compressors to facilitate the flow of oil from the compressor with the relatively higher pressure to the compressor with the relatively lower pressure.