Embodiments of systems and methods for fast input/output (IO) on PCIE devices are described. Such methods include receiving an IO request from a user or application, the IO request comprising instructions for communicating data with a host system, the host system comprising a processing device and a memory device, analyzing information from the IO request in an IO block analyzer to select one of a plurality of communication paths for communicating the data with the host system, defining a routing instruction in a transfer routing information transmitter in response to the selected communication path, communicating the routing instruction in a Transaction Layer Packet (TLP) to an integrated IO (IIO) module of the host system routing the data from the peripheral device to either the processing device or the memory device according to the routing instruction with a data transfer router.