- 专利标题: Composition containing monoacetyldiglyceride compound as active ingredient for preventing or treating chronic obstructive pulmonary disease
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申请号: US15857933申请日: 2017-12-29
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公开(公告)号: US10765655B2公开(公告)日: 2020-09-08
- 发明人: Sei-Ryang Oh , Kyung Seop Ahn , Su Ui Lee , In Sik Shin , Ok-Kyoung Kwon , Seung Hyung Kim , Chan Mi Chun , Tae-Suk Lee , Yong-Hae Han , Ki Young Sohn , JongKoo Kang , Hye Kyung Kim
- 申请人: ENZYCHEM LIFESCIENCES CORPORATION , KOREA RESEARCH INSTITUTE OF BIO SCIENCE AND BIOTECHNOLOGY
- 申请人地址: KR Daejeon KR Daejeon
- 专利权人: Enzychem Lifesciences Corporation,Korea Research Institute of BioScience and Biotechnology
- 当前专利权人: Enzychem Lifesciences Corporation,Korea Research Institute of BioScience and Biotechnology
- 当前专利权人地址: KR Daejeon KR Daejeon
- 代理机构: Mintz Levin Cohn Ferris Glovsky and Popeo, P.C.
- 代理商 Peter F. Corless
- 优先权: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@3ed8152a
- 主分类号: A61K31/231
- IPC分类号: A61K31/231
摘要:
The present invention relates to a pharmaceutical composition containing a monoacetyldiacylglycerol compound as an active ingredient for preventing or treating chronic obstructive pulmonary diseases, and a functional health food composition for treating or preventing chronic obstructive pulmonary diseases. The monoacetyldiacylglycerol compound of the present invention inhibits the IL-4 expression in EL-4 cells and inhibits the infiltration of inflammatory cells into the bronchial tube in an animal model. In addition, the compounds of the present invention have an excellent effect of inhibiting the expression of CXCL-1, TNF-α, or MIP-2, thereby overcoming side effects of the currently used therapeutic agents for chronic obstructive pulmonary diseases, having no toxicity, and exhibiting a superior therapeutic effect, and thus can be useful as a composition for preventing, treating, and alleviating chronic obstructive pulmonary diseases.
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