公开(公告)号：US12076307B2

公开(公告)日：2024-09-03

申请号：US16888716

申请日：2020-05-30

申请人： Enzychem Lifesciences Corporation

发明人： Ki Young Sohn ,  Sun Young Yoon

IPC分类号： A61K31/231 ,  A61K38/19 ,  A61K45/06 ,  A61P39/00 ,  A61P43/00

CPC分类号： A61K31/231 ,  A61K38/193 ,  A61K45/06 ,  A61P39/00 ,  A61P43/00

摘要： In one aspect, use of 1-palmitoyl-2-linoleoyl-3-acetylglycerol (PLAG) for treating or preventing acute radiation syndrome is provided.

公开(公告)号：US20240238238A1

公开(公告)日：2024-07-18

申请号：US18621682

申请日：2024-03-29

申请人： BioJiva LLC

发明人： Mikhail Sergeevich Shchepinov

IPC分类号： A61K31/231 ,  A61K31/201 ,  A61P25/28

CPC分类号： A61K31/231 ,  A61K31/201 ,  A61P25/28

摘要： Isotopically modified polyunsaturated fatty acid or ester thereof, such as 11,11-D2-linoleic acid or its ethyl ester, and uses of the same for treating or ameliorating the symptoms of Friedreich's ataxia are disclosed.

公开(公告)号：US20240216321A1

公开(公告)日：2024-07-04

申请号：US18527530

申请日：2023-12-04

申请人： DSM IP Assets B.V.

发明人： Adriana CARVALHO DE SOUZA ,  Peter Louis HOUSTON ,  Valmik Kanubhai VYAS ,  Angela WILDERMANN

IPC分类号： A61K31/23 ,  A61K31/01 ,  A61K31/045 ,  A61K31/07 ,  A61K31/11 ,  A61K31/231

CPC分类号： A61K31/23 ,  A61K31/01 ,  A61K31/045 ,  A61K31/07 ,  A61K31/11 ,  A61K31/231

摘要： Compositions of matter suitable for use in food, feed, pharmaceutical, and beauty care products comprising a retinoid component and a fermentative residue thereof are disclosed herein. In an embodiment, the retinoid component is present in a ratio by weight relative to the fermentative residue of 4:1 or greater, wherein the retinoid contains cis- and trans-isomers, wherein the cis-isomers are present by weight relative to the entire mixture of isomers in an amount less than 3 wt. %. Preferably, the compositions are bio-based. Also described are biotechnological methods of producing the compositions elsewhere described, along with further methods for processing such compositions into more stabilized, more commercially acceptable forms. Finally, also disclosed are food, feed, pharmaceutical, and beauty care products incorporating the compositions herein described.

公开(公告)号：US11975086B2

公开(公告)日：2024-05-07

申请号：US17809661

申请日：2022-06-29

申请人： KAO CORPORATION

发明人： Toshiaki Ozawa ,  Takaya Sakai ,  Mariko Miyoshi ,  Daisuke Furukawa ,  Aya Shirai

IPC分类号： A61K8/41 ,  A61K8/36 ,  A61K8/37 ,  A61K8/39 ,  A61K8/44 ,  A61K8/46 ,  A61K8/49 ,  A61K31/075 ,  A61K31/08 ,  A61K31/133 ,  A61K31/198 ,  A61K31/225 ,  A61K31/23 ,  A61K31/231 ,  A61K31/25 ,  A61K31/351 ,  A61K31/5375 ,  A61K45/06 ,  A61P17/00 ,  A61P17/10 ,  A61Q19/00 ,  A61Q19/10

CPC分类号： A61K8/41 ,  A61K8/361 ,  A61K8/37 ,  A61K8/375 ,  A61K8/39 ,  A61K8/44 ,  A61K8/463 ,  A61K8/466 ,  A61K8/49 ,  A61K8/498 ,  A61K31/075 ,  A61K31/08 ,  A61K31/133 ,  A61K31/198 ,  A61K31/225 ,  A61K31/23 ,  A61K31/231 ,  A61K31/25 ,  A61K31/351 ,  A61K31/5375 ,  A61K45/06 ,  A61P17/00 ,  A61P17/10 ,  A61Q19/00 ,  A61Q19/10 ,  A61K2800/596

摘要： A method for removing keratotic plugs capable of sufficiently exhibiting an excellent keratotic plug-removing effect without a burden, such as pam and of irritation, on the skin. The method comprises applying a composition comprising (X) one or more selected from (X1) 2-amino-2-hydroxymethyl-1,3-propanediol, (X2) 2-amino-2-methyl-1-propanol, and (X3) 2-amino-2-methyl-1,3-propanediol and a nonionic surfactant to the skin.

公开(公告)号：US20240058293A1

公开(公告)日：2024-02-22

申请号：US18382446

申请日：2023-10-20

申请人： Emory University ,  Children's Healthcare of Atlanta, Inc.

发明人： Claudia R. Morris

IPC分类号： A61K31/23 ,  A61K31/202 ,  A61K31/122 ,  A61K31/07 ,  A61K31/59 ,  A61K38/46 ,  A61K31/7004 ,  A61K31/473 ,  A61K35/741 ,  A61K33/26 ,  A61K31/661 ,  A61K33/18 ,  A61K33/34 ,  A61K33/32 ,  A61K33/24 ,  A61K31/047 ,  A61K31/385 ,  A61K31/205 ,  A61K31/375 ,  A61K33/30 ,  A61K31/355 ,  A23L33/175 ,  A23L33/15 ,  A23L33/12 ,  A61K31/22 ,  A61K33/42 ,  A23L33/00 ,  A61K45/06 ,  A23L33/16 ,  A61K31/19 ,  A61K31/4375 ,  A23L33/155 ,  A61K31/231 ,  A61K9/00 ,  A61K31/232 ,  A61K31/20 ,  A23L33/135

CPC分类号： A61K31/23 ,  A61K31/202 ,  A61K31/122 ,  A61K31/07 ,  A61K31/59 ,  A61K38/46 ,  A61K31/7004 ,  A61K31/473 ,  A61K35/741 ,  A61K33/26 ,  A61K31/661 ,  A61K33/18 ,  A61K33/34 ,  A61K33/32 ,  A61K33/24 ,  A61K31/047 ,  A61K31/385 ,  A61K31/205 ,  A61K31/375 ,  A61K33/30 ,  A61K31/355 ,  A23L33/175 ,  A23L33/15 ,  A23L33/12 ,  A61K31/22 ,  A61K33/42 ,  A23L33/40 ,  A61K45/06 ,  A23L33/16 ,  A61K31/19 ,  A61K31/4375 ,  A23L33/155 ,  A61K31/231 ,  A61K9/0056 ,  A61K31/232 ,  A61K31/20 ,  A23L33/135 ,  A23V2002/00 ,  A61K2035/115

摘要： Disclosed are nutritional formulations and uses for treating or preventing a gastrointestinal condition and/or motor-planning speech and/or coordination difficulties. In certain embodiments, the nutritional formulations comprise medium chain fatty acids, or esters thereof (such as and tri-, di-, mono-glycerides, or alkyl esters), unsaturated fatty acids, and a vitamin E and optionally other nutrients. In certain embodiments, any of the compounds or nutrients may be in alternative salt forms.

公开(公告)号：US20240041027A1

公开(公告)日：2024-02-08

申请号：US18257539

申请日：2020-12-14

申请人： Javier Eduardo LÓPEZ MACÍAS

发明人： Alejandro PÉREZ LARIOS

IPC分类号： A01N25/08 ,  A61K36/9062 ,  A61P31/06 ,  A61K36/63 ,  A01N65/36 ,  A61K36/85 ,  A61K36/886 ,  A61K31/045 ,  A01N31/02 ,  A61K31/085 ,  A01N35/04 ,  A61K36/9068 ,  A61K36/54 ,  A61K36/53 ,  A61K36/61 ,  A01N65/08 ,  A61K36/24 ,  A61K36/282 ,  A01N65/38 ,  A01N31/08 ,  A01N35/02 ,  A01N65/48 ,  A61P31/12 ,  A61K36/28 ,  A61K31/122 ,  A01N27/00 ,  A61K31/231 ,  A61K36/232 ,  A61K36/268 ,  A61K36/9066 ,  A61K36/35 ,  A01P3/00 ,  A01P1/00 ,  A01N65/12 ,  A61K36/185 ,  A61K36/30 ,  A61K36/52 ,  A61K36/746 ,  A61K36/235 ,  A61K36/66 ,  A61K36/14 ,  A61K31/015 ,  A61K31/11 ,  A61K31/121 ,  A61K31/01 ,  A61K36/288 ,  A61K36/87 ,  A01N65/24 ,  A61K36/484 ,  A61P31/04 ,  A01N65/22 ,  A61K36/738 ,  A01N65/28 ,  A61K36/21 ,  A61K36/537 ,  A61K36/81 ,  A01N35/06 ,  A61K36/31 ,  A01N65/44 ,  A61P31/10 ,  A61K36/752 ,  A61K36/68 ,  A61K36/534 ,  A61K36/67 ,  A01N37/06 ,  A01N65/10 ,  A61K36/899 ,  A01N65/34 ,  A61K36/75 ,  A61K36/15 ,  A61K31/05 ,  A01N31/14

CPC分类号： A01N25/08 ,  A61K36/9062 ,  A61P31/06 ,  A61K36/63 ,  A01N65/36 ,  A61K36/85 ,  A61K36/886 ,  A61K31/045 ,  A01N31/02 ,  A61K31/085 ,  A01N35/04 ,  A61K36/9068 ,  A61K36/54 ,  A61K36/53 ,  A61K36/61 ,  A01N65/08 ,  A61K36/24 ,  A61K36/282 ,  A01N65/38 ,  A01N31/08 ,  A01N35/02 ,  A01N65/48 ,  A61P31/12 ,  A61K36/28 ,  A61K31/122 ,  A01N27/00 ,  A61K31/231 ,  A61K36/232 ,  A61K36/268 ,  A61K36/9066 ,  A61K36/35 ,  A01P3/00 ,  A01P1/00 ,  A01N65/12 ,  A61K36/185 ,  A61K36/30 ,  A61K36/52 ,  A61K36/746 ,  A61K36/235 ,  A61K36/66 ,  A61K36/14 ,  A61K31/015 ,  A61K31/11 ,  A61K31/121 ,  A61K31/01 ,  A61K36/288 ,  A61K36/87 ,  A01N65/24 ,  A61K36/484 ,  A61P31/04 ,  A01N65/22 ,  A61K36/738 ,  A01N65/28 ,  A61K36/21 ,  A61K36/537 ,  A61K36/81 ,  A01N35/06 ,  A61K36/31 ,  A01N65/44 ,  A61P31/10 ,  A61K36/752 ,  A61K36/68 ,  A61K36/534 ,  A61K36/67 ,  A01N37/06 ,  A01N65/10 ,  A61K36/899 ,  A01N65/34 ,  A61K36/75 ,  A61K36/15 ,  A61K31/05 ,  A01N31/14

摘要： The instant invention refers to nanosystems comprising nanocomposites for adsorption or support of natural extracts; a process for the preparation thereof; formulations containing thereof, as well as a nanomaterial that adsorbs one or more essential oils in its surface. Specially, one object of the invention is the encapsulation of natural extracts, i.e., essential oils and/or natural pure bioactive compounds and optionally terpenoid, sesquiterpenoid, diterpenoid, sesterterpenoid, triterpenoid, carotenoid, and ricinoid compounds; complementary acids, and polysaccharides; vitamins, and other organic compounds, in mesoporous materials for application in different industries such as food, agricultural, veterinary, aquacultural, pharmaceutical, cosmetic, cleaning, sanitizing, and disinfection industries, as well as in medicine.

公开(公告)号：US20230181515A1

公开(公告)日：2023-06-15

申请号：US18078414

申请日：2022-12-09

申请人： ARTI VASHIST ,  PREM CHAPAGAIN ,  ANDREA RAYMOND ,  HITENDRA CHAND ,  MADHAVAN NAIR

发明人： ARTI VASHIST ,  PREM CHAPAGAIN ,  ANDREA RAYMOND ,  HITENDRA CHAND ,  MADHAVAN NAIR

IPC分类号： A61K31/231 ,  A61P31/14

CPC分类号： A61K31/231 ,  A61P31/14

摘要： The present invention is directed to a method of treatment or prevention of viral and/or bacterial infection comprising the administration of a polyol derived from a vegetable oil or its derivative. The vegetable oil is preferably linseed oil. The invention is also directed to a formulation comprising a vegetable oil-derived polyol.

公开(公告)号：US20230157997A9

公开(公告)日：2023-05-25

申请号：US17388257

申请日：2021-07-29

申请人： CAAMTECH, INC.

发明人： Andrew R. CHADEAYNE

IPC分类号： A61K31/675 ,  A61K31/7048 ,  A61K31/704 ,  A61K31/352 ,  A61K31/231 ,  A61K31/23 ,  A61K31/4406

CPC分类号： A61K31/675 ,  A61K31/7048 ,  A61K31/704 ,  A61K31/352 ,  A61K31/231 ,  A61K31/23 ,  A61K31/4406

摘要： Disclosed herein are compositions comprising a serotonergic tryptamine compound, combinations thereof, and methods of using them for treating and preventing a variety of human conditions. In one embodiment, disclosed herein are new compositions and methods which comprise a therapeutically effective amount of a first purified psilocybin derivative and a therapeutically effective amount of a second compound. The second compound is selected from the group consisting of a second purified psilocybin derivative, a purified terpene, a serotonergic drug, an adrenergic drug, a dopaminergic drug, a purified erinacine, and a purified hericenone.

公开(公告)号：US20220378734A1

公开(公告)日：2022-12-01

申请号：US17665436

申请日：2022-02-04

申请人： RETROTOPE, INC.

发明人： Mikhail S. SHCHEPINOV

IPC分类号： A61K31/232 ,  A61K31/122 ,  A61K31/20 ,  A61K31/201 ,  A61K31/202 ,  A61K31/355 ,  A61K31/375 ,  A61K31/231 ,  A61K45/06

摘要： Some aspects of the invention provide for a method of treating Alzheimer's Disease, Mild Cognitive Impairment, Frontotemperal Dementia, Amyotrophic Lateral Sclerosis and/or Multiple Sclerosis using polyunsaturated fatty acids which are modified in certain positions to attenuate oxidative damage by Reactive Oxygen Species (ROS) and/or suppress the rate of formation of reactive products and toxic compounds.

公开(公告)号：US20220257616A1

公开(公告)日：2022-08-18

申请号：US17597659

申请日：2020-07-17

申请人： BAKER HEART AND DIABETES INSTITUTE

发明人： Peter John Meikle

IPC分类号： A61K31/661 ,  A61P3/02 ,  A61P3/04 ,  A61P3/10 ,  A61K31/231 ,  A23L33/00 ,  A23L33/12

摘要： Provided herein is a composition comprising a mixture of ether lipid molecules of Formula (I) as defined herein. The composition is for invivo maintenance of ether lipids at levels and/or ratios associated with a non-disease state, or wherein the composition is for in vivo modification of ether lipids towards levels and/or ratios associated with a non-disease state. Also provided herein are methods of assessing subject for metabolic disease or dyslipidemia, comprising measuring relative abundance of one or more ether lipid side chains in a biological sample from a subject, methods of preventing or treating disorders such as metabolic disease or dyslipidemia, or methods of preventing conditions such as obesity and asthma, particularly in infants, involving administering a composition as defined herein.