Disclosed is an anatomical drape, such as a dental drape, for covering a treatment area of an anatomical part. The drape includes an elastomeric material capable of conforming to the contours of the anatomical part. The drape preferably includes a curing agent. Activation of the curing agent, for example by a light source, causes selective hardening of the stretched material to at least partially set the drape in a configuration conforming to the anatomical part. The semi-rigid set drape preferably is liquid impermeable but gas permeable. A method of manufacturing the drape is also disclosed.