In a method of operating a display panel, a plurality of data lines are divided into a first data line group through an N-th data line group, where N is a natural number equal to or greater than two. Each of the first through N-th data line groups includes at least two data lines. The first through N-th data line groups are sequentially driven by applying first data voltages through N-th data voltages to the first through N-th data line groups, respectively at different times. A first number of data lines in the first data line group is variable.