Invention Grant
- Patent Title: Catalytic hydrogenation of substituted cyanopyridines and process for preparing substituted pyridylmethylbenzamides
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Application No.: US15569528Application Date: 2016-04-26
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Publication No.: US10781176B2Publication Date: 2020-09-22
- Inventor: Wahed Ahmed Moradi , Günter Schlegel , Albert Schnatterer , Frank Volz
- Applicant: BAYER CROPSCIENCE AKTIENGESELLSCHAFT
- Applicant Address: DE Monheim am Rhein
- Assignee: BAYER CROPSCIENCE AKTIENGESELLSCHAFT
- Current Assignee: BAYER CROPSCIENCE AKTIENGESELLSCHAFT
- Current Assignee Address: DE Monheim am Rhein
- Agency: McBee Moore & Vanik IP, LLC
- Priority: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@c6cbc12
- International Application: PCT/EP2016/059215 WO 20160426
- International Announcement: WO2016/173998 WO 20161103
- Main IPC: C07D213/61
- IPC: C07D213/61 ; C07D213/40

Abstract:
The present invention relates to novel processes for the preparation of substituted pyridyl-methylbenzamide derivatives of formula (I), in particular 2,6-dichloro-N-{[3-chloro-5-(trifluoromethyl)-2-pyridyl]methyl}benzamide (Fluopicolide), and for the catalytic hydrogenation of substituted cyanopyridine derivatives, in particular 3-chloro-2-cyano-5-trifluoromethylpyridine [=Py-CN] to the corresponding substituted 2-methylaminopyridine derivatives, in particular 2-aminomethyl-3-chloro-5-trifluoromethylpyridine [=Py-methylamine] or salts thereof in the presence of metal catalysts such as in particular palladium catalysts, catalytic modifiers and acids.
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