公开(公告)号：US10781176B2

公开(公告)日：2020-09-22

申请号：US15569528

申请日：2016-04-26

Applicant: BAYER CROPSCIENCE AKTIENGESELLSCHAFT

Inventor： Wahed Ahmed Moradi ,  Günter Schlegel ,  Albert Schnatterer ,  Frank Volz

IPC: C07D213/61 ,  C07D213/40

Abstract: The present invention relates to novel processes for the preparation of substituted pyridyl-methylbenzamide derivatives of formula (I), in particular 2,6-dichloro-N-{[3-chloro-5-(trifluoromethyl)-2-pyridyl]methyl}benzamide (Fluopicolide), and for the catalytic hydrogenation of substituted cyanopyridine derivatives, in particular 3-chloro-2-cyano-5-trifluoromethylpyridine [=Py-CN] to the corresponding substituted 2-methylaminopyridine derivatives, in particular 2-aminomethyl-3-chloro-5-trifluoromethylpyridine [=Py-methylamine] or salts thereof in the presence of metal catalysts such as in particular palladium catalysts, catalytic modifiers and acids.

公开(公告)号：US10125103B2

公开(公告)日：2018-11-13

申请号：US15569681

申请日：2016-04-28

Applicant: Bayer CropScience Aktiengesellschaft

Inventor： Sergii Pazenok ,  Hans Martin Thomas ,  Frank Volz

IPC: C07D231/16

Abstract: The present invention relates to a novel method for preparing 5-fluoro-1H-pyrazole-4-carbonyl fluorides by halogen exchange reaction of 5-chloro-1H-pyrazole-4-carbonyl chlorides with alkali metal fluorides, using non-polar solvents.

公开(公告)号：US10647674B2

公开(公告)日：2020-05-12

申请号：US15569528

申请日：2016-04-26

Applicant: BAYER CROPSCIENCE AKTIENGESELLSCHAFT

Inventor： Wahed Ahmed Moradi ,  Günter Schlegel ,  Albert Schnatterer ,  Frank Volz

IPC: C07D213/61 ,  C07D213/40

Abstract: The present invention relates to novel processes for the preparation of substituted pyridyl-methylbenzamide derivatives of formula (I), in particular 2,6-dichloro-N-{[3-chloro-5-(trifluoromethyl)-2-pyridyl]methyl}benzamide (Fluopicolide), and for the catalytic hydrogenation of substituted cyanopyridine derivatives, in particular 3-chloro-2-cyano-5-trifluoromethylpyridine [=Py-CN] to the corresponding substituted 2-methylaminopyridine derivatives, in particular 2-aminomethyl-3-chloro-5-trifluoromethylpyridine [=Py-methylamine] or salts thereof in the presence of metal catalysts such as in particular palladium catalysts, catalytic modifiers and acids.