An I2C and Manchester multiple serial interface LED driver programmer has a programmer that changes the operation parameters in the EEPROM of the LED driver via a computer graphic user interface. The LED driver operation is thus programmed according to the parameters stored in the EEPROM. The multiple interfaces are selectable as USB-to-I2C, RS232-to-I2C, USB-to-TxD/RxD, RS232-to-TxD/RxD and 3rd via a pass through USB-to-USB port for expanded LED programming interface such as Near Field Communication. The I2C and Manchester multiple serial interface LED driver has multiple output interface with USB-to-I2C, RS232-to-I2C, USB-to-TxD/RxD, RS232-to-TxD/RxD and third pass through USB-to-USB port for Near Field Communication interface.