- Patent Title: Small molecule myristate inhibitors of BCR-ABL and methods of use
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Application No.: US16170921Application Date: 2018-10-25
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Publication No.: US10787455B2Publication Date: 2020-09-29
- Inventor: Nathanael Gray , Jianming Zhang , Barun Okram , Xianming Deng , Jae Won Chang , Amy Wojciechowski
- Applicant: Dana-Farber Cancer Institute, Inc. , The Scripps Research Institute
- Applicant Address: US MA Boston US CA La Jolla
- Assignee: DANA-FARBER CANCER INSTITUTE, INC.,THE SCRIPPS RESEARCH INSTITUTE
- Current Assignee: DANA-FARBER CANCER INSTITUTE, INC.,THE SCRIPPS RESEARCH INSTITUTE
- Current Assignee Address: US MA Boston US CA La Jolla
- Agency: Brinks Gilson & Lione
- Agent Yuezhong Feng
- Main IPC: C07D487/04
- IPC: C07D487/04 ; C07D239/94 ; A61P9/00 ; A61P35/02 ; A61P19/00 ; A61P35/00 ; A61P17/00 ; C07D239/42 ; C07D403/04 ; C07D403/06 ; C07D403/12 ; C07D417/04 ; C07D473/34 ; C07D495/04 ; A61K31/517 ; A61K31/519 ; A61K31/52 ; A61K31/5377 ; A61K31/7076 ; A61K45/06 ; C07D471/04 ; C07H19/16
Abstract:
The present invention provides novel heteroaryl compounds of formula (I) having a pyrimidine-containing core that is linked to a 4-trifluoromethoxyphenyl group via an amine linker. Such compounds are useful for the treatment of cancers.
Public/Granted literature
- US20190084990A1 SMALL MOLECULE MYRISTATE INHIBITORS OF BCR-ABL AND METHODS OF USE Public/Granted day:2019-03-21
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