A vehicle opening and closing body operating device includes: a full-open lock opening lever connected to a full-open lock configured to maintain an opening and closing body in a fully opened state, and configured to output release operating force to the full-open lock; an input lever connected to the full-open lock opening lever and an operating handle, and configured to rotate the full-open lock opening lever so as to output the release operating force; a release lever connected to the input lever through a connecting member, and configured to rotate the full-open lock opening lever through the connecting member and the input lever; an emergency input lever to which rotation operating force is inputted; and a cancel mechanism configured to move the connecting member from a connection position where the input and release levers are connected to a disconnection position where the input and release levers are disconnected.