- Patent Title: Disubstituted and trisubstituted 1,2,3-triazoles as Wnt inhibitors
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Application No.: US16330050Application Date: 2017-08-31
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Publication No.: US10793544B2Publication Date: 2020-10-06
- Inventor: Nageswari Yarravarapu , Chuo Chen , Lawrence Lum , Lin You , Chengwei Zhang , Xiaolei Wang , Lishu Zhang
- Applicant: The Board of Regents of the University of Texas System
- Agency: Parker Highlander PLLC
- International Application: PCT/US2017/049634 WO 20170831
- International Announcement: WO2018/045182 WO 20180308
- Main IPC: C07D401/12
- IPC: C07D401/12 ; C07D401/14 ; C07D409/14 ; A61K31/4192 ; C07D405/14 ; A61K31/506 ; A61K31/4439 ; A61K31/444 ; A61K45/06 ; C07D255/02

Abstract:
The present disclosure provides compounds that may be useful for inhibiting Wnt pathway comprising compounds of the formula: (Ia) or (Ib) wherein the variables are as defined herein. In some aspects, the compounds may be used to inhibit the Wnt pathway and used to treat cancer, myocardial infarction, osteopetrosis, or used in the maturation of a precursor cell to a mature cell. Also provided herein in are pharmaceutical compositions of the compounds described herein.
Public/Granted literature
- US20190202804A1 DISUBSTITUTED AND TRISUBSTITUTED 1,2,3-TRIAZOLES AS WNT INHIBITORS Public/Granted day:2019-07-04
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