公开(公告)号：US11492368B2

公开(公告)日：2022-11-08

申请号：US16903173

申请日：2020-06-16

Applicant: The Board of Regents of the University of Texas System

Inventor： Zhijian Chen ,  Lijun Sun ,  Jiaxi Wu ,  Heping Shi ,  Chuo Chen

IPC: C07H21/02 ,  A61K39/39 ,  A61K31/7084 ,  C12Q1/6876 ,  C12Q1/25 ,  G01N33/573 ,  G01N33/564 ,  A61K39/00

Abstract: Cyclic-GMP-AMP synthase (cGAS) and cyclic-GMP-AMP (cGAMP), including 2′3-cGAMP, 2′2-cGAMP, 3′2′-cGAMP and 3′3′-GAMP, are used in pharmaceutical formulations (including vaccine adjuvants), drug screens, therapies, and diagnostics.

公开(公告)号：US10947206B2

公开(公告)日：2021-03-16

申请号：US15953494

申请日：2018-04-15

Applicant: ImmuneSensor Therapeutics, Inc. ,  The Board of Regents of the University of Texas System

Inventor： Boyu Zhong ,  Lijun Sun ,  Heping Shi ,  Jing Li ,  Chuo Chen ,  Zhijian Chen

IPC: C07D277/34 ,  C07D417/14 ,  A61K31/429 ,  A61K31/4365 ,  A61K31/4439 ,  A61K31/506 ,  A61K31/519 ,  A61K31/427 ,  C07D277/40 ,  A61K31/437 ,  A61K31/426 ,  A61K31/381 ,  A61K31/433 ,  A61K31/4709 ,  A61K39/39 ,  A61K45/06 ,  A61K31/454 ,  A61K31/4725 ,  A61K31/497 ,  A61K31/4985 ,  A61K31/501 ,  C07D277/36 ,  C07D403/06 ,  C07D417/04 ,  C07D417/06 ,  C07D417/10 ,  C07D417/12 ,  C07D471/04 ,  C07D495/04 ,  C07D513/04

Abstract: Disclosed are novel compounds of Formula I that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

公开(公告)号：US20250115564A1

公开(公告)日：2025-04-10

申请号：US18759546

申请日：2024-06-28

Applicant: IMMUNESENSOR THERAPEUTICS, INC. ,  THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Boyu Zhong ,  Lijun Sun ,  Heping Shi ,  Jing Li ,  Chuo Chen ,  Zhijian Chen

IPC: C07D277/34 ,  A61K31/381 ,  A61K31/426 ,  A61K31/427 ,  A61K31/429 ,  A61K31/433 ,  A61K31/4365 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/497 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/506 ,  A61K31/519 ,  A61K39/39 ,  A61K45/06 ,  C07D277/36 ,  C07D277/40 ,  C07D403/06 ,  C07D417/04 ,  C07D417/06 ,  C07D417/10 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04 ,  C07D513/04

Abstract: Disclosed are novel compounds of Formula I that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

公开(公告)号：US11013704B2

公开(公告)日：2021-05-25

申请号：US15312790

申请日：2015-05-12

Applicant: The Board of Regents of the University of Texas System

Inventor： Chengcheng Zhang ,  Yi Liu ,  Junke Zheng ,  Mi Deng ,  Chuo Chen ,  Jiawei Liu

IPC: A61K31/194 ,  A61K31/197 ,  C12N5/078 ,  C12N5/0789 ,  A61K31/155 ,  A61K31/20 ,  C07C279/14 ,  A61K45/06 ,  A61K35/65 ,  A61K38/01

Abstract: The present disclosure relates to methods of using a compound to induce regeneration of hematopoietic stem cells or increase the recovery of red blood cells. In some aspects, the present methods can be used to with or in place of erythropoietin in patients to mitigate the side effects of erythropoietin.

公开(公告)号：US10420758B2

公开(公告)日：2019-09-24

申请号：US15571240

申请日：2016-05-02

Applicant: The Board of Regents of the University of Texas System

Inventor： Lawrence Lum ,  Chuo Chen ,  Xuewu Zhang ,  Ozlem Kulak ,  Xiaofeng Wu

IPC: A61K31/454 ,  A61K45/06

Abstract: The present disclosure provides compounds that may be useful for inhibiting the Tankyrase enzyme. In some aspects, these compounds are useful in the treatment of a disease or disorder related to the misregulation of Tankyrase enzyme such as cancer, degenerative diseases, or fibrotic diseases. Also provided herein are compounds may also be used to prevent the elongation of the telomere in a cell.

公开(公告)号：US20150157633A1

公开(公告)日：2015-06-11

申请号：US14400001

申请日：2013-05-06

Applicant: The Board of Regents of the University of Texas System

Inventor： Lawrence Lum ,  Michael Roth ,  Baozhi Chen ,  Michael Dodge ,  Chuo Chen

IPC: A61K31/519 ,  A61K31/495 ,  A61K31/42 ,  A61K31/4709 ,  A61K45/06 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/453 ,  A61K31/353 ,  A61K31/444 ,  A61K31/517

CPC classification number: A61K31/519 ,  A61K31/353 ,  A61K31/366 ,  A61K31/42 ,  A61K31/421 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/453 ,  A61K31/4709 ,  A61K31/495 ,  A61K31/496 ,  A61K31/517 ,  A61K45/06 ,  A61K2300/00

Abstract: The present invention generally relates to protein signalling. In particular, compounds that inhibit the Wnt protein signalling pathway are disclosed. Such compounds may be used in the treatment of Wnt protein signalling-related diseases and conditions such as cancer, degenerative diseases, type II diabetes and osteopetrosis.

Abstract translation: 本发明一般涉及蛋白信号传导。 特别地，公开了抑制Wnt蛋白信号通路的化合物。 这些化合物可用于治疗Wnt蛋白信号传导相关疾病和病症如癌症，退行性疾病，II型糖尿病和骨细胞减少症。

公开(公告)号：US20250115579A1

公开(公告)日：2025-04-10

申请号：US18829953

申请日：2024-09-10

Applicant: IMMUNESENSOR THERAPEUTICS, INC. ,  THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Jian Qiu ,  Qi Wei ,  Matt Tschantz ,  Heping Shi ,  Youtong Wu ,  Huiling Tan ,  Lijun Sun ,  Chuo Chen ,  Zhijian Chen

IPC: C07D401/14 ,  C07D215/38 ,  C07D215/42 ,  C07D215/46 ,  C07D401/04 ,  C07D403/04 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/08 ,  C07D491/048 ,  C07F9/6503 ,  C07F9/6506

Abstract: The present disclosure provides compounds that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

公开(公告)号：US12134609B2

公开(公告)日：2024-11-05

申请号：US18334325

申请日：2023-06-13

Applicant: IMMUNESENSOR THERAPEUTICS, INC. ,  THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Jian Qiu ,  Qi Wei ,  Matt Tschantz ,  Heping Shi ,  Youtong Wu ,  Huiling Tan ,  Lijun Sun ,  Chuo Chen ,  Zhijian Chen

IPC: C07D401/14 ,  C07D215/38 ,  C07D215/42 ,  C07D215/46 ,  C07D401/04 ,  C07D403/04 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/08 ,  C07D491/048 ,  C07F9/6503 ,  C07F9/6506

Abstract: The present disclosure provides compounds that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

公开(公告)号：US12091387B2

公开(公告)日：2024-09-17

申请号：US18353718

申请日：2023-07-17

Applicant: IMMUNESENSOR THERAPEUTICS, INC. ,  THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Qi Wei ,  Heping Shi ,  Matt Tschantz ,  Jian Qiu ,  Youtong Wu ,  Huiling Tan ,  Lijun Sun ,  Chuo Chen ,  Zhijian Chen

IPC: C07D215/12 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

CPC classification number: C07D215/12 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

Abstract: The present disclosure provides compounds that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

公开(公告)号：US10519188B2

公开(公告)日：2019-12-31

申请号：US15953492

申请日：2018-04-15

Applicant: ImmuneSensor Therapeutics, Inc. ,  The Board of Regents of the University of Texas System

Inventor： Boyu Zhong ,  Lijun Sun ,  Heping Shi ,  Qi Wei ,  Yuanwei Dai ,  Chuo Chen ,  Zhijian Chen

IPC: C07H21/04 ,  A61K31/7084 ,  C07H21/02 ,  A61K45/06

Abstract: Disclosed are cyclic-di-nucleotide cGAMP analogs, methods of synthesizing the compounds, pharmaceutical compositions comprising the compounds thereof, and use of compounds and compositions in medical therapy.