Invention Grant
- Patent Title: Toll-like receptor 7 (TLR7) agonists having heteroatom-linked aromatic moieties, conjugates thereof, and methods and uses therefor
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Application No.: US16865009Application Date: 2020-05-01
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Publication No.: US10793569B2Publication Date: 2020-10-06
- Inventor: Liqi He , Sanjeev Gangwar , Yam B. Poudel , Prasanna Sivaprakasam
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: BRISTOL-MYERS SQUIBB COMPANY
- Current Assignee: BRISTOL-MYERS SQUIBB COMPANY
- Current Assignee Address: US NJ Princeton
- Agent Yuan Chao
- Main IPC: A61K31/52
- IPC: A61K31/52 ; A61K31/522 ; C07D473/18 ; C07D473/04 ; A61P37/04 ; A61K47/68
Abstract:
Compounds having a structure according to formula (I) or (II) where R1, R2, R3, R4, Ar and X1 are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.
Public/Granted literature
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