Invention Grant
- Patent Title: Therapeutic spalt-like transcription factor 4 (SALL4) peptide
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Application No.: US16095603Application Date: 2017-04-28
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Publication No.: US10793601B2Publication Date: 2020-10-06
- Inventor: Bee Hui Liu , Daniel Geoffrey Tenen , Li Chai , Cheng San Brian Chia , Anders Poulsen
- Applicant: National University of Singapore , The Brigham and Women's Hospital, Inc. , Agency for Science, Technology and Research
- Applicant Address: SG Singapore US MA Boston SG Singapore
- Assignee: National University of Singapore,The Brigham and Women's Hospital, Inc.,Agency for Science, Technology and Research
- Current Assignee: National University of Singapore,The Brigham and Women's Hospital, Inc.,Agency for Science, Technology and Research
- Current Assignee Address: SG Singapore US MA Boston SG Singapore
- Agency: Fish & Richardson P.C.
- International Application: PCT/US2017/030164 WO 20170428
- International Announcement: WO2017/190032 WO 20171102
- Main IPC: A61K38/00
- IPC: A61K38/00 ; A61K38/08 ; C07K7/06 ; C07K7/08
Abstract:
Isolated peptides and pharmaceutical compositions comprising isolated peptides that bind to retinoblastoma binding protein 4 (RBBp4) and block the Spalt-Like Transcription Factor 4 (SALL4)-RBBp4 interaction are described. Methods of inhibiting binding of SALL4 to RBBp4 and methods of treating a subject having a disorder mediated by a dysregulation of SALL4 are also described.
Public/Granted literature
- US20190218253A1 Therapeutic SALL4 Peptide Public/Granted day:2019-07-18
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