- 专利标题： Methods and compositions for treating drug resistance in cancer
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申请号： US15904176申请日： 2018-02-23
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公开(公告)号： US10813935B2公开(公告)日： 2020-10-27
- 发明人: Subhra Mohapatra , Shyam S. Mohapatra , Mark Howell , Rajesh Nair
- 申请人： UNIVERSITY OF SOUTH FLORIDA , TRANSGENEX NANOBIOTECH, INC.
- 申请人地址： US FL Lutz US FL Tampa
- 专利权人： TRANSGENEX NANOBIOTECH, INC.,University of South Florida
- 当前专利权人： TRANSGENEX NANOBIOTECH, INC.,University of South Florida
- 当前专利权人地址： US FL Lutz US FL Tampa
- 代理机构： Fish & Richardson P.C.
- 主分类号： A61K31/517
- IPC分类号： A61K31/517 ; A61P35/00 ; A61K31/496
摘要：
Disclosed herein are compositions and methods for treating cancer. Further provided herein are compositions and methods for reducing, inhibiting, or preventing resistance of cancer to tyrosine kinase inhibitors. The methods may include administering an anti-resistance agent such as a CYP51A1 inhibitor or an agonist of miRNA-764 (SEQ ID NO: 4) to a subject. A tyrosine kinase inhibitor may also be administered to the subject in addition to the anti-resistance agent.
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