- 专利标题: Triazolone compounds as mPGES-1 inhibitors
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申请号: US16423992申请日: 2019-05-28
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公开(公告)号: US10821100B2公开(公告)日: 2020-11-03
- 发明人: Laxmikant A. Gharat , Nagarajan Muthukaman , Neelima Khairatkar-Joshi , Vidya G. Kattige
- 申请人: Glenmark Pharmaceuticals S.A.
- 申请人地址: CH La Chaux-de-Fonds
- 专利权人: Ichnos Sciences SA
- 当前专利权人: Ichnos Sciences SA
- 当前专利权人地址: CH La Chaux-de-Fonds
- 代理机构: Blank Rome LLP
- 优先权: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@620196ce com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@768a1b1b com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@45649331
- 主分类号: A61K31/4196
- IPC分类号: A61K31/4196 ; C07D401/04 ; C07D401/10 ; C07D403/04 ; C07D403/10 ; C07D403/12 ; C07D405/12 ; C07D409/14 ; C07D413/10 ; C07D417/10 ; C07D417/12 ; A61K31/4245 ; A61K31/428 ; A61K31/433 ; A61K31/4439 ; A61K31/5377 ; C07D249/12 ; C07D413/12 ; A61K31/422
摘要:
The present disclosure is directed to compounds of formula (I), and pharmaceutically acceptable salts thereof, as mPGES-1 inhibitors. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful in the treatment of pain and/or inflammation from a variety of diseases or conditions, such as asthma, osteoarthritis, rheumatoid arthritis, acute or chronic pain and neurodegenerative diseases.
公开/授权文献
- US20190282548A1 TRIAZOLONE COMPOUNDS AS MPGES-1 INHIBITORS 公开/授权日:2019-09-19
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