A process for making a seamless, reversible two-color jersey, including the following steps: knitting with a wholegarment knitting machine in such manner to make a seamless reversible jersey; closing the bottom and the cuffs of the jersey, making tracks on the sides of each sleeve and of the body, dry-cleaning the jersey, removing the stains, finishing the jersey, tacking a patch on the jersey to cover the opening generated by the neck, pre-ironing the jersey, dyeing the jersey, wherein the dye color is absorbed in a different way on the external surface of the jersey and on the internal surface of the jersey, in such manner to obtain a two-color jersey, removing the patch and the seals of the bottom and of the cuffs.