Invention Grant
- Patent Title: Processes and intermediates for NEP inhibitor synthesis
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Application No.: US16325880Application Date: 2017-08-16
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Publication No.: US10851059B2Publication Date: 2020-12-01
- Inventor: Florian Karl Kleinbeck-Riniker , Ives Mafli , Benjamin Martin , Gerhard Penn , Gottfried Sedelmeier , Joerg Sedelmeier , Francesco Venturoni
- Applicant: Novartis AG
- Applicant Address: CH Basel
- Assignee: Novartis AG
- Current Assignee: Novartis AG
- Current Assignee Address: CH Basel
- Agent Judith D. Kuntz
- Priority: EP16184589 20160817
- International Application: PCT/IB2017/054976 WO 20170816
- International Announcement: WO2018/033866 WO 20180222
- Main IPC: C07C271/22
- IPC: C07C271/22 ; C07D213/16 ; C07C201/12 ; C07C251/38 ; C07C201/16 ; C07C205/53 ; C07C249/08 ; C07D213/36 ; C07C205/51 ; C07C67/347 ; C07C231/02 ; C07C269/00 ; C07C201/06 ; C07C227/18 ; C07C45/49 ; C07C229/06 ; C07C249/02 ; C07D207/267 ; C07D207/12
Abstract:
The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril, inter alia via nitro 5 compounds. It further relates to new intermediate compounds and their use for said new chemical synthesis route, as well as a new catalyst ligand.
Public/Granted literature
- US20190202785A1 NEW PROCESSES AND INTERMEDIATES FOR NEP INHIBITOR SYNTHESIS Public/Granted day:2019-07-04
Information query
