公开(公告)号：US11434192B2

公开(公告)日：2022-09-06

申请号：US16452452

申请日：2019-06-25

申请人： Novartis AG

发明人： Florian Karl Kleinbeck-Riniker ,  Benjamin Martin ,  Gerhard Penn ,  Francesco Venturoni ,  Thierry Schlama ,  Thomas Ruch ,  Thomas Allmendinger ,  Bernhard Wietfeld ,  Paolo Filipponi

IPC分类号： C07C59/84 ,  C07C67/035 ,  C07C213/08 ,  C07C69/738 ,  C07C313/06 ,  C07C229/34 ,  C07D265/02 ,  C07D207/36 ,  C07C251/40 ,  C07C251/66 ,  C07C51/373

摘要： The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril. It further relates to new intermediate compounds and their use for said new chemical synthesis route.

公开(公告)号：US10851059B2

公开(公告)日：2020-12-01

申请号：US16325880

申请日：2017-08-16

申请人： Novartis AG

发明人： Florian Karl Kleinbeck-Riniker ,  Ives Mafli ,  Benjamin Martin ,  Gerhard Penn ,  Gottfried Sedelmeier ,  Joerg Sedelmeier ,  Francesco Venturoni

IPC分类号： C07C271/22 ,  C07D213/16 ,  C07C201/12 ,  C07C251/38 ,  C07C201/16 ,  C07C205/53 ,  C07C249/08 ,  C07D213/36 ,  C07C205/51 ,  C07C67/347 ,  C07C231/02 ,  C07C269/00 ,  C07C201/06 ,  C07C227/18 ,  C07C45/49 ,  C07C229/06 ,  C07C249/02 ,  C07D207/267 ,  C07D207/12

摘要： The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril, inter alia via nitro 5 compounds. It further relates to new intermediate compounds and their use for said new chemical synthesis route, as well as a new catalyst ligand.

公开(公告)号：US10385004B2

公开(公告)日：2019-08-20

申请号：US15550224

申请日：2016-02-11

申请人： Novartis AG

发明人： Benjamin Martin ,  Francesca Mandrelli ,  Francesco Venturoni

IPC分类号： C07C201/10 ,  C07C201/12 ,  C07C227/04 ,  C07C335/16 ,  C07F9/535 ,  C07D207/06 ,  B01J31/02 ,  C07C205/04 ,  C07C205/44 ,  C07C205/51 ,  C07F7/18

摘要： The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril. It further relates to new intermediate compounds and their use for said new chemical synthesis route.

公开(公告)号：US10377697B2

公开(公告)日：2019-08-13

申请号：US15780957

申请日：2016-12-08

申请人： Novartis AG

发明人： Florian Karl Kleinbeck-Riniker ,  Benjamin Martin ,  Gerhard Penn ,  Francesco Venturoni ,  Thierry Schlama ,  Thomas Ruch ,  Thomas Allmendinger ,  Bernhard Wietfeld ,  Paolo Filipponi

IPC分类号： C07C51/373 ,  C07C69/738 ,  C07C313/06 ,  C07C229/34 ,  C07D265/02 ,  C07D207/36 ,  C07C251/40 ,  C07C251/66 ,  C07C59/84 ,  C07C67/035

摘要： The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril. It further relates to new intermediate compounds and their use for said new chemical synthesis route.