A fire and water resistant, integrated wall and roof expansion joint seal system includes an expansion joint seal for a structure. The seal includes a central portion having an underside and at least one central chamber disposed around a centerline, a first flange portion extending outwardly from the centerline and a second flange portion extending outwardly from the centerline in a direction opposite the first flange portion. The system further includes a joint closure. The joint closure includes a core and a layer of a water resistant material disposed on the core. The joint closure further includes an end portion configured to match and integrate with the underside of the central portion to form the watertight, integrated wall and roof expansion joint seal system. A fire retardant material is included in the core in an amount effective to pass testing mandated by UL 2079, and the core with the fire retardant material therein is configured to facilitate compression of the core when installed between the first substrate and the second substrate by repeatedly expanding and contracting to accommodate movement of the first substrate and the second substrate; and the core with the fire retardant material included therein is configured to pass the testing mandated by UL 2079. Movement of one or both of the first substrate and the second substrate causes a response in the central portion to maintain the seal.