A vehicle electronics high-resistance fault diagnosis system is provided, as well as a method of detecting and isolating a high-resistance fault in vehicle electronics of a vehicle. The method includes the steps of determining electrical data for one or more portions of the vehicle electronics, wherein the electrical data includes voltage data and/or current data concerning the one or more portions of the vehicle electronics; calculating a resistance for a plurality of resistance sets of the vehicle electronics based on the electrical data, wherein each of the plurality of resistance sets includes one or more electrical components; obtaining a resistance set threshold for each of the plurality of resistance sets of the vehicle electronics; for each of the plurality of resistance sets, evaluating whether the resistance of the resistance set exceeds the resistance set threshold; and based on the evaluating step, identifying one or more high-resistance fault candidates.