Embodiments of a multi-form factor Information Handling System (IHS) with automatically reconfigurable hardware keys with automatically reconfigurable hardware keys are described. In an illustrative, non-limiting embodiment, an IHS may include: a processor; and a memory coupled to the processor, the memory having program instructions stored thereon that, upon execution by the processor, cause the IHS to: identify a posture of a second display relative to a first display; and in response to a keyboard event, execute a command selected, at least in part, based upon the posture.