A method of compensating for non-uniform luminance of a display panel including first pixels in a center region and second pixels in a non-center region, the method including displaying a for-compensation image, generating a luminance image by capturing an image of an entire region of the display panel, extracting luminance values of the first pixels from the luminance image by analyzing the luminance image, calculating and storing compensation factors for the first pixels based on the luminance values thereof, calculating compensation factors for the second pixels by performing an interpolation between a reference compensation factor determined for an edge of the non-center region and compensation factors for edge pixels on an edge of the center region when a displaying operation is performed, and compensating image data using the compensation factors for the first pixels and the second pixels when the displaying operation is performed on the display panel.