- Patent Title: Methods of identifying signaling modulators of the trimeric TNFa
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Application No.: US15736336Application Date: 2015-10-22
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Publication No.: US10883996B2Publication Date: 2021-01-05
- Inventor: James Philip O'Connell , John Robert Porter , Alastair Lawson , Boris Kroeplien , Stephen Edward Rapecki , Timothy John Norman , David James McMillan , Graham John Warrellow , Daniel Christopher Brookings , Rikki Peter Alexander
- Applicant: UCB BIOPHARMA SRL
- Applicant Address: BE Brussels
- Assignee: UCB BIOPHARMA SRL
- Current Assignee: UCB BIOPHARMA SRL
- Current Assignee Address: BE Brussels
- Agency: Medler Ferro Woodhouse & Mills PLLC
- Priority: GB1510758.4 20150618
- International Application: PCT/EP2015/074490 WO 20151022
- International Announcement: WO2016/202411 WO 20161222
- Main IPC: G01N33/68
- IPC: G01N33/68 ; C07K14/525 ; C07K14/705 ; C07K16/24 ; C07D401/14 ; C07D471/00 ; C07D213/72 ; C07D235/04 ; C07D239/26 ; C07D471/04 ; A61K47/64 ; A61P37/00 ; A61P35/00
Abstract:
The invention is in the field of TNF signalling. Compounds have been identified which are capable of modulating signalling of TNF trimers through receptors. Methods of identifying such compounds are therefore provided. The compounds themselves have utility in therapy.
Public/Granted literature
- US20180203016A1 MECHANISM OF ACTION Public/Granted day:2018-07-19
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