公开(公告)号：US11174311B2

公开(公告)日：2021-11-16

申请号：US16470999

申请日：2017-12-13

申请人： UCB BIOPHARMA SRL ,  SANOFI

发明人： Alastair David Griffiths Lawson ,  Daniel John Lightwood ,  Rebecca Jayne Munro ,  James Philip O'Connell ,  John Robert Porter

IPC分类号： C07K16/24

摘要： It has been demonstrated that certain compounds bind to TNF and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Antibodies which selectively bind to complexes of such compounds with TNF superfamily members are disclosed. These antibodies may be used to detect further compounds with the same activity, and as target engagement biomarker.

公开(公告)号：US10969393B2

公开(公告)日：2021-04-06

申请号：US15736535

申请日：2015-10-22

申请人： UCB Biopharma SRL

发明人： James Philip O'Connell ,  John Robert Porter ,  Alastair Lawson ,  Daniel John Lightwood ,  Rebecca Jayne Munro

IPC分类号： C07D401/14 ,  C07K14/525 ,  C07D471/00 ,  C07K14/705 ,  C07K16/24 ,  C07D213/72 ,  C07D235/04 ,  C07D239/26 ,  C07D471/04 ,  A61K47/64 ,  A61P37/00 ,  A61P35/00 ,  G01N33/68

摘要： It has been demonstrated that certain compounds bind to TNF and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Antibodies which selectively bind to complexes of such compounds with TNF superfamily members are disclosed. These antibodies may be used to detect further compounds with the same activity, and as target engagement biomarker.

公开(公告)号：US11674967B2

公开(公告)日：2023-06-13

申请号：US17013326

申请日：2020-09-04

申请人： UCB BIOPHARMA SRL

发明人： James Philip O'Connell ,  John Robert Porter ,  Alastair Lawson ,  Boris Kroeplien ,  Stephen Edward Rapecki ,  Timothy John Norman ,  Graham John Warrellow ,  Tracy Lynn Arakaki ,  Alex Buntin Burgin ,  William Ross Pitt ,  Mark Daniel Calmiano ,  David Andreas Schubert ,  Daniel John Lightwood ,  Rebecca Jayne Munro

IPC分类号： G01N33/68 ,  C07D401/14 ,  C07K14/525 ,  C07D471/00 ,  C07K14/705 ,  C07K16/24 ,  C07D213/72 ,  C07D235/04 ,  C07D239/26 ,  C07D471/04 ,  A61K47/64 ,  A61P37/00 ,  A61P35/00

CPC分类号： G01N33/6845 ,  A61K47/6425 ,  A61P35/00 ,  A61P37/00 ,  C07D213/72 ,  C07D235/04 ,  C07D239/26 ,  C07D401/14 ,  C07D471/00 ,  C07D471/04 ,  C07K14/525 ,  C07K14/70575 ,  C07K16/241 ,  G01N33/6854 ,  G01N33/6863 ,  C07K2317/55 ,  C07K2317/92 ,  G01N2333/525 ,  G01N2500/02

摘要： A new, stable trimeric TNFα structure is disclosed with distorted symmetry which can bind to the TNFR1 receptor to attenuate signalling therefrom, which can be used in the treatment and/or prevention of diseases associated with the soluble TNFα/TNFR1 interaction. Membrane-bound TNFα is not affected in its ability to signal through TNFR2, and thus the new structure of TNFα may be used in therapies which do not significantly raise the risk of infection or malignancy.

公开(公告)号：US10935553B2

公开(公告)日：2021-03-02

申请号：US15736535

申请日：2015-10-22

申请人： UCB Biopharma SRL

发明人： James Philip O'Connell ,  John Robert Porter ,  Alastair Lawson ,  Daniel John Lightwood ,  Rebecca Jayne Munro

IPC分类号： C07D401/14 ,  C07K14/525 ,  C07D471/00 ,  C07K14/705 ,  C07K16/24 ,  C07D213/72 ,  C07D235/04 ,  C07D239/26 ,  C07D471/04 ,  A61K47/64 ,  A61P37/00 ,  A61P35/00 ,  G01N33/68

摘要： It has been demonstrated that certain compounds bind to TNF and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Antibodies which selectively bind to complexes of such compounds with TNF superfamily members are disclosed. These antibodies may be used to detect further compounds with the same activity, and as target engagement biomarker.

公开(公告)号：US11448655B2

公开(公告)日：2022-09-20

申请号：US16883859

申请日：2020-05-26

申请人： UCB BIOPHARMA SRL

发明人： James Philip O'Connell ,  John Robert Porter ,  Alastair Lawson ,  Boris Kroeplien ,  Stephen Edward Rapecki ,  Timothy John Norman ,  Graham John Warrellow

IPC分类号： G01N33/68 ,  C07K14/525 ,  C07K16/24 ,  A61K47/64 ,  A61P37/00 ,  A61P35/00 ,  C07D401/14 ,  C07D471/00 ,  C07K14/705 ,  C07D213/72 ,  C07D235/04 ,  C07D239/26 ,  C07D471/04

摘要： It has been demonstrated that certain compounds bind to TNF and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Accordingly, these compounds can be used as modulators of TNF. A new assay for identifying compounds with this mechanism of action is also disclosed.

公开(公告)号：US10883996B2

公开(公告)日：2021-01-05

申请号：US15736336

申请日：2015-10-22

申请人： UCB BIOPHARMA SRL

发明人： James Philip O'Connell ,  John Robert Porter ,  Alastair Lawson ,  Boris Kroeplien ,  Stephen Edward Rapecki ,  Timothy John Norman ,  David James McMillan ,  Graham John Warrellow ,  Daniel Christopher Brookings ,  Rikki Peter Alexander

IPC分类号： G01N33/68 ,  C07K14/525 ,  C07K14/705 ,  C07K16/24 ,  C07D401/14 ,  C07D471/00 ,  C07D213/72 ,  C07D235/04 ,  C07D239/26 ,  C07D471/04 ,  A61K47/64 ,  A61P37/00 ,  A61P35/00

摘要： The invention is in the field of TNF signalling. Compounds have been identified which are capable of modulating signalling of TNF trimers through receptors. Methods of identifying such compounds are therefore provided. The compounds themselves have utility in therapy.

公开(公告)号：US10705094B2

公开(公告)日：2020-07-07

申请号：US15736520

申请日：2015-10-22

申请人： UCB Biopharma SRL

发明人： James Philip O'Connell ,  John Robert Porter ,  Alastair Lawson ,  Boris Kroeplien ,  Stephen Edward Rapecki ,  Timothy John Norman ,  Graham John Warrellow

IPC分类号： G01N33/68 ,  C07K14/525 ,  C07K14/705 ,  C07K16/24 ,  A61K47/64 ,  A61P37/00 ,  C07D401/14 ,  C07D471/00 ,  C07D213/72 ,  C07D235/04 ,  C07D239/26 ,  C07D471/04 ,  A61P35/00

摘要： It has been demonstrated that certain compounds bind to TNF and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Accordingly, these compounds can be used as modulators of TNF. A new assay for identifying compounds with this mechanism of action is also disclosed.

公开(公告)号：US12055549B2

公开(公告)日：2024-08-06

申请号：US17325036

申请日：2021-05-19

申请人： UCB Biopharma SRL ,  SANOFI

发明人： James Philip O'Connell ,  John Robert Porter ,  Alastair Lawson ,  Tracy Lynn Arakaki ,  Daniel John Lightwood ,  Rebecca Jayne Munro

IPC分类号： G01N33/68 ,  A61K47/64 ,  A61P35/00 ,  A61P37/00 ,  C07D213/72 ,  C07D235/04 ,  C07D239/26 ,  C07D401/14 ,  C07D471/00 ,  C07D471/04 ,  C07K14/525 ,  C07K14/705 ,  C07K16/24

CPC分类号： G01N33/6845 ,  A61K47/6425 ,  A61P35/00 ,  A61P37/00 ,  C07D213/72 ,  C07D235/04 ,  C07D239/26 ,  C07D401/14 ,  C07D471/00 ,  C07D471/04 ,  C07K14/525 ,  C07K14/70575 ,  C07K16/241 ,  G01N33/6854 ,  G01N33/6863 ,  C07K2317/55 ,  C07K2317/92 ,  G01N2333/525 ,  G01N2500/02

摘要： It has been demonstrated that certain compounds bind to TNF and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Antibodies which selectively bind to complexes of such compounds with TNF superfamily members are disclosed. These antibodies may be used to detect further compounds with the same activity, and as target engagement biomarker.

公开(公告)号：US11022614B2

公开(公告)日：2021-06-01

申请号：US15736558

申请日：2015-10-22

申请人： UCB BIOPHARMA SRL ,  SANOFI

发明人： James Philip O'Connell ,  John Robert Porter ,  Alastair Lawson ,  Tracy Lynn Arakaki ,  Daniel John Lightwood ,  Rebecca Jayne Munro

IPC分类号： C07K14/525 ,  C07K16/24 ,  G01N33/68 ,  C07D401/14 ,  C07D471/00 ,  C07K14/705 ,  C07D213/72 ,  C07D235/04 ,  C07D239/26 ,  C07D471/04 ,  A61K47/64 ,  A61P37/00 ,  A61P35/00

摘要： It has been demonstrated that certain compounds bind to TNF and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Antibodies which selectively bind to complexes of such compounds with TNF superfamily members are disclosed. These antibodies may be used to detect further compounds with the same activity, and as target engagement biomarker.