The present invention provides a molecular network, devices, and assays for early diagnosis of ischemic cardiac events in patients experiencing chest pain. The invention allows for the differentiation of chest pain due to ischemic cardiac events and other non-cardiac causes. The invention provides a Nourin-based RNA molecular network composed of lncRNA-CTB89H12.4, hsa-miRNA-137, and FTLH-17 mRNA as an autophagy-related RNA panel linked to each other and to cardiovascular ischemia to specifically diagnose ischemic cardiac events. The invention further demonstrates that the down-regulation of RNA-CTB89H12.4 after an AMI event, resulted in the up-regulation of hsa-miRNA-137 and activation of FTLH-17 mRNA with an increased translation and production of Nourin protein; a cardiac-derived biomarker. These Nourin multiple genes can, therefore, be used alone, and in combination with the protein-based Nourin measured by antibodies comprising of the epitope sequence f-MII to increase the early diagnosis of ischemic cardiac patients with a high degree of accuracy.