The present disclosure disclose example video stream transmission methods and related devices and systems. One example method includes sending, by a client, a target request to a server, where the target request includes information about a corresponding target spatial location of a target spatial object that needs to be presented upon request by the client in a virtual reality VR content component. A target request feedback by which the server responds to the target request is received by the client, where the target request feedback includes information about a multiplex video stream that is obtained by performing preset multiplexing processing on an original video stream corresponding to the target spatial object. Video parsing and presentation based on the information about the multiplex video stream is performed by the client.