- 专利标题： Engineered tyrosine ammonia lyase
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申请号： US16436176申请日： 2019-06-10
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公开(公告)号： US10900055B2公开(公告)日： 2021-01-26
- 发明人: Gjalt W. Huisman , Joyce Liu , Nikki Dellas , Chinping Chng , William Casey Hallows
- 申请人： Codexis, Inc.
- 申请人地址： US CA Redwood City
- 专利权人： Codexis, Inc.
- 当前专利权人： Codexis, Inc.
- 当前专利权人地址： US CA Redwood City
- 代理机构： Codexis, Inc.
- 主分类号： C12N9/88
- IPC分类号： C12N9/88 ; C12P7/42 ; C12P13/22 ; C12N15/63 ; A61K9/00 ; A61K31/122
摘要：
The present invention provides engineered tyrosine ammonia-lyase (TAL) polypeptides and compositions thereof. In some embodiments, the engineered TAL polypeptides have been optimized to provide enhanced catalytic activity and enhanced acid stability, while reducing sensitivity to proteolysis and increasing tolerance to acidic pH levels. The invention also provides methods for utilization of the compositions comprising the engineered TAL polypeptides for therapeutic and industrial purposes.
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