Example embodiments relate to an integrated lens-free imaging device. One embodiment includes a lens-free imaging device for imaging a sample. The lens-free imaging device includes a radiation guiding structure that includes a first surface parallel with a second surface. The lens-free imaging device also includes an imaging region. The radiation guiding structure is adapted for receiving an incoming radiation wave, thereby obtaining a confined radiation wave. At least one perturbation is present in the radiation guiding structure for generating, from the confined radiation wave, a first radiation wave and a second radiation wave. The radiation guiding structure is configured to direct the first radiation wave out of the radiation guiding structure toward the first surface to a sample measurement region. The radiation guiding structure is further configured to direct the second radiation wave toward the second surface to the imaging region.