- 专利标题： Toll-like receptor 7 (TLR7) agonists having a heterobiaryl moiety, conjugates thereof, and methods and uses therefor
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申请号： US16904337申请日： 2020-06-17
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公开(公告)号： US10927114B2公开(公告)日： 2021-02-23
- 发明人: Liqi He , Sanjeev Gangwar , Shoshana L. Posy , Yam B. Poudel , Prasanna Sivaprakasam
- 申请人： BRISTOL-MYERS SQUIBB COMPANY
- 申请人地址： US NJ Princeton
- 专利权人： BRISTOL-MYERS SQUIBB COMPANY
- 当前专利权人： BRISTOL-MYERS SQUIBB COMPANY
- 当前专利权人地址： US NJ Princeton
- 代理商 Yuan Chao
- 主分类号： C07D473/16
- IPC分类号： C07D473/16 ; C07D473/18 ; A61P37/04 ; A61K47/60 ; A61K47/68 ; A61K31/52
摘要：
Compounds having a structure according to formula (I) or (II) where R1, R2, and Ar are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.
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