A sealing element of a motor vehicle may include a body, at least one first region, and at least one second region. The at least one first region may be composed of a first material. The at least one second region may be composed of a second material having a higher chemical resistance than the first material. A distribution of the at least one first region and a distribution of the at least one second region in a cross-sectional profile of the body may be variable in a longitudinal direction extending perpendicular to the cross-sectional profile of the body.