- 专利标题： Method for preparing organoboron derivative containing oxygen and aromatic ring as labeled precursor of dopamine positron emission tomography imaging agent
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申请号： US16994860申请日： 2020-08-17
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公开(公告)号： US10934314B1公开(公告)日： 2021-03-02
- 发明人: Yu Chang , Wen-Ching Wu
- 申请人： INSTITUTE OF NUCLEAR ENERGY RESEARCH, ATOMIC ENERGY COUNCIL, EXECUTIVE YUAN, R.O.C.
- 申请人地址： TW Taoyuan
- 专利权人： INSTITUTE OF NUCLEAR ENERGY RESEARCH, ATOMIC ENERGY COUNCIL, EXECUTIVE YUAN, R.O.C.
- 当前专利权人： INSTITUTE OF NUCLEAR ENERGY RESEARCH, ATOMIC ENERGY COUNCIL, EXECUTIVE YUAN, R.O.C.
- 当前专利权人地址： TW Taoyuan
- 代理机构： Rosenberg, Klein & Lee
- 优先权： TW108139508 20191031
- 主分类号： C07F5/02
- IPC分类号： C07F5/02 ; G01N33/60 ; B01D11/02 ; B01D15/08
摘要：
A method for preparing organoboron derivatives containing oxygen atoms and an aromatic ring as labeled precursors of dopamine positron emission tomography imaging agents is revealed. Hydrochloride salt of cocaine is used as an initiator. Organoboron derivatives containing oxygen atoms are directly produced on an aromatic ring as drug substances and the aromatic ring is directly labeled with radioisotope fluorine-18 (F-18). The method takes only five steps including four steps for preparing organoboron derivatives containing oxygen atoms and an aromatic ring as drug substances and a step of labeling the aromatic ring of the organoboron derivatives with F-18 directly. Not only the process time is significantly reduced, the total yield rate is also improved effectively.