公开(公告)号：US20220365093A1

公开(公告)日：2022-11-17

申请号：US17721054

申请日：2022-04-14

申请人： Dewpoint Therapeutics, Inc.

发明人： Alexander SZEWCZAK ,  Ina POSER ,  Mark Andrew MURCKO ,  Stephen Paul HALE ,  Bruce Aaron BEUTEL

IPC分类号： G01N33/68 ,  G01N33/50 ,  G01N33/58 ,  G01N33/60

摘要： Methods of identifying a compound, such as a test compound, and applications thereof are provided. For example, methods of identifying a compound that preferentially affects, increases, or decreases a level of association of a macromolecule with one or more target condensates or methods of identifying a compound that preferentially causes a macromolecule to associate or disassociate with one or more target condensates are provided. Additionally, methods of designing and/or identifying and/or making a compound, or portion thereof, with a desired characteristic are provided.

公开(公告)号：US11459400B2

公开(公告)日：2022-10-04

申请号：US15745496

申请日：2016-07-15

申请人： The University of Chicago

发明人： Shohei Koide ,  Shun-Ichi Tanaka ,  Akiko Koide

IPC分类号： G01N33/53 ,  G01N33/569 ,  G01N33/573 ,  C07K16/40 ,  C12Q1/26 ,  C12Q1/34 ,  C12Q1/48 ,  C12Q1/527 ,  C12Q1/533 ,  C12Q1/00 ,  C12N9/38 ,  C07K14/78 ,  C12N9/20 ,  C12Q1/25 ,  G01N33/58 ,  G01N33/60

摘要： Aspects of the disclosure relate to compositions of enzyme-binding polypeptides (EBPs) that modify the substrate specificity of an enzyme and a method for identifying an EBP that modifies substrate specificity of an enzyme binding at least one substrate, the method comprising: contacting the enzyme with a polypeptide library comprising a plurality of EBPs that bind different epitopes of the enzyme; identifying EBPs that bind to the enzyme to form an EBP-enzyme complex; assaying for the activity level and substrate specificity of the EBP-enzyme complex; and identifying EBPs that modify the substrate specificity of the enzyme by identifying EBPs that, when in an EBP-enzyme complex, have a different substrate specificity than un-complexed EBP; wherein the catalytic rate constant of the EBP-enzyme complex is ≥50% of the un-complexed enzyme for at least one substrate and/or wherein the EBP-enzyme complex retains binding to a substrate.

公开(公告)号：US20220298216A1

公开(公告)日：2022-09-22

申请号：US17832813

申请日：2022-06-06

申请人： James L. Hougland

发明人： James L. Hougland

IPC分类号： C07K14/63 ,  G01N33/58 ,  G01N33/573 ,  G01N33/60

摘要： Imaging agents that can bind to ghrelin O-acyltransferase (GOAT) without binding to the ghrelin receptor (GHS-R1a). The imaging agents comprise a base structure for selective binding to GOAT that is coupled via an amino acid linker to a chemical group to enable imaging such as a fluorescent label, radioactive tracer, or metal chelator. For example, the imaging agent may comprise a ghrelin substrate mimetic inhibitor incorporating an unmodified 2,3-diaminopropanoic acid (Dap) group at the site analogous to serine 3. These agents enable specific detection and imaging of GOAT versus the GHS-R1a receptor in a variety of biological contexts.

公开(公告)号：US20220236259A1

公开(公告)日：2022-07-28

申请号：US17658119

申请日：2022-04-06

申请人： Siemens Healthcare Diagnostics Inc.

发明人： Kayla Cortese ,  Saji Cherian ,  Paul D'Agostino ,  Gabriel Hammarquist ,  Aili Han ,  Kuldeep Jaggi ,  Maral Poladian ,  Niver Sahakian ,  Seema Sinha ,  Prakash Tewari ,  Haekyung Lee

IPC分类号： G01N33/543 ,  G01N33/58 ,  G01N33/60

摘要： Disclosed herein are immunoassays for detecting an anti-thyroid peroxidase antibody in a biological sample from a subject and/or diagnosing a thyroid disease in a subject. The disclosed immunoassays employ a recombinant cynomolgus monkey thyroid peroxidase (rTPO) and assess the level of anti-thyroid peroxidase antibody-induced formation or disruption of complexes comprising a solid support and the rTPO.

公开(公告)号：US11385144B2

公开(公告)日：2022-07-12

申请号：US16079451

申请日：2017-02-23

申请人： NOUL CO., LTD.

发明人： Dong Young Lee ,  Chan Yang Lim ,  Kyung Hwan Kim

IPC分类号： G01N1/31 ,  G01N1/30 ,  C12Q1/6844 ,  C12Q1/6848 ,  G01N33/50 ,  G01N21/77 ,  G01N33/558 ,  B01L3/00 ,  G01N15/06 ,  G01N33/52 ,  G01N33/574 ,  G01N15/14 ,  G01N33/49 ,  G01N33/60 ,  C12Q1/686 ,  C07K16/30 ,  C12Q1/70 ,  G01N33/483 ,  G06T7/00 ,  G01N33/53 ,  G01N33/533 ,  B01L7/00 ,  G01N15/00

摘要： The present disclosure relates to an immunoassay method for performing immunoassay by using a patch that contains antibodies. An immunoassay method according to an aspect of the present disclosure performs diagnosis by detecting a target protein from a sample to be diagnosed by using a patch which includes a mesh structural body forming micro-cavities and is configured to contain a liquid substance in the micro-cavities, and includes placing the sample to be diagnosed in a reaction region, and providing an antibodies that react specifically with a target protein to the reaction region by using a patch that contains the antibodies.

公开(公告)号：US11353457B2

公开(公告)日：2022-06-07

申请号：US16916273

申请日：2020-06-30

申请人： ID-Fish Technology, Inc.

发明人： Jyotsna S. Shah ,  Song Liu

IPC分类号： G01N33/569 ,  G01N33/58 ,  G01N33/68 ,  G01N33/60

摘要： Compositions and methods for the detection and identification of Tick-Borne Relapsing Fever Borrelia sp. antibodies.

公开(公告)号：US20220024882A1

公开(公告)日：2022-01-27

申请号：US17298321

申请日：2019-11-28

申请人： ITM Isotopen Technologien München AG ,  Paul Scherrer Institut

发明人： Martina Benesova ,  Cristina Müller ,  Christoph Umbricht ,  Roger Schibli ,  Konstantin Zhernosekov ,  Luisa Maria Deberle

IPC分类号： C07D257/02 ,  A61K51/04 ,  A61P35/00 ,  G01N33/60

摘要： The present invention provides compounds according to General Formula (1)(i) or (1)(ii): wherein A is a diagnostic or therapeutic agent comprising a binding site for a tumor antigen, and the spacer comprises at least one C—N bond.

公开(公告)号：US11084873B2

公开(公告)日：2021-08-10

申请号：US16426585

申请日：2019-05-30

申请人： National Health Research Institutes

发明人： Feng-Shiun Shie ,  Tsu-An Hsu ,  Chuan Shih ,  Santai Shen

IPC分类号： C07K16/18 ,  A61P25/28 ,  G01N33/68 ,  G01N33/60 ,  A61K39/00

摘要： An isolated antibody, comprising a light-chain CDR1 (L-CDR1) having the sequence of SEQ ID NO: 1, SEQ ID NO: 7, or SEQ ID NO: 14; a light-chain CDR2 (L-CDR2) having the sequence of SEQ ID NO: 2 or SEQ ID NO: 15; a light-chain CDR3 (L-CDR3) having the sequence of SEQ ID NO: 3, SEQ ID NO: 8, SEQ ID NO: 21, or SEQ ID NO: 24; a heavy-chain CDR1 (H-CDR1) having the sequence of SEQ ID NO: 4, SEQ ID NO: 9, SEQ ID NO: 11, SEQ ID NO: 16, or SEQ ID NO: 25; a heavy-chain CDR2 (H-CDR2) having the sequence of SEQ ID NO: 5, SEQ ID NO: 12, SEQ ID NO: 17, SEQ ID NO: 19, SEQ ID NO: 22, or SEQ ID NO: 26; and a heavy-chain CDR3 (H-CDR3) having the sequence of SEQ ID NO: 6, SEQ ID NO: 10, SEQ ID NO: 13, SEQ ID NO: 18, SEQ ID NO: 20, SEQ ID NO: 23, or SEQ ID NO: 27, wherein the antibody specifically binds to Aβ1-42 or an N-terminal modified form thereof.

公开(公告)号：US20210208153A1

公开(公告)日：2021-07-08

申请号：US17203005

申请日：2021-03-16

申请人： c/o Dewpoint Therapeutics, Inc.

发明人： Alexander SZEWCZAK ,  Ina POSER ,  Mark Andrew MURCKO ,  Stephen Paul HALE ,  Bruce Aaron BEUTEL

IPC分类号： G01N33/68 ,  G01N33/58 ,  G01N33/60 ,  G01N33/50

摘要： Methods of identifying a compound, such as a test compound, and applications thereof are provided. For example, methods of identifying a compound that preferentially affects, increases, or decreases a level of association of a macromolecule with one or more target condensates or methods of identifying a compound that preferentially causes a macromolecule to associate or disassociate with one or more target condensates are provided. Additionally, methods of designing and/or identifying and/or making a compound, or portion thereof, with a desired characteristic are provided.

公开(公告)号：US11040119B2

公开(公告)日：2021-06-22

申请号：US14774510

申请日：2014-03-12

申请人： Biogen MA Inc.

发明人： Ajay Verma ,  Jack Hoppin

IPC分类号： A61K51/04 ,  A61B5/00 ,  G01N33/60 ,  G01N33/68

摘要： The invention provides compositions and methods for evaluating neuromuscular function in a subject, e.g., a subject at risk for or suffering from a neuromuscular disorder.