A method of making an integrated circuit includes operations to identify reverse signal nets of the circuit layout, determine when the conductive lines to the reverse signal net have parasitic capacitance, and determine how to adjust an integrated circuit layout to reduce the parasitic capacitance of the conductive lines to the reverse signal net. The method further includes an operation to determine whether to move one of the conductive lines in the integrated circuit layout, and an operation to determine whether to insert an isolation structure between the conductive lines of the reverse signal net having parasitic capacitance.