Invention Grant
- Patent Title: Tyrosine amide derivatives as Rho-Kinase inhibitors
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Application No.: US16656842Application Date: 2019-10-18
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Publication No.: US10954236B2Publication Date: 2021-03-23
- Inventor: Alessandro Accetta , Fabio Rancati , Anna Maria Capelli , David Edward Clark , Patrizia Tisselli , Christine Edwards , Gurdip Bhalay , Arnaud Jean Francois Auguste Cheguillaume
- Applicant: CHIESI FARMACEUTICI S.P.A.
- Applicant Address: IT Parma
- Assignee: CHIESI FARMACEUTICI S.P.A.
- Current Assignee: CHIESI FARMACEUTICI S.P.A.
- Current Assignee Address: IT Parma
- Agency: Oblon, McClelland, Maier & Neustadt, L.L.P.
- Priority: EP17153785 20170130
- Main IPC: A61P11/00
- IPC: A61P11/00 ; C07D471/04 ; C07D519/00 ; C07D487/04 ; A61K9/00 ; A61K31/437 ; A61K31/4375 ; A61K31/439 ; A61K31/444 ; A61K31/4725 ; A61K31/496 ; A61K31/498 ; A61K31/4985 ; A61K31/501 ; A61K31/519 ; A61K31/5377 ; A61K31/5383 ; C07D471/08 ; C07D498/04
Abstract:
Bicyclic dihydropyrimidine-carboxamide compounds of formula I described herein inhibit Rho Kinase and may be used for the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).
Public/Granted literature
- US20200079774A1 TYROSINE AMIDE DERIVATIVES AS RHO- KINASE INHIBITORS Public/Granted day:2020-03-12
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