公开(公告)号：US20180170939A1

公开(公告)日：2018-06-21

申请号：US15850720

申请日：2017-12-21

Applicant: CHIESI FARMACEUTICI S.p.A.

Inventor： Alessandro Accetta ,  Fabio Rancati ,  Anna Maria Capelli ,  David Edward Clark ,  Patrizia Tisselli ,  Christine Edwards ,  Gurdip Bhalay

IPC: C07D487/04 ,  A61K31/519 ,  A61K45/06 ,  A61K9/00 ,  A61P11/06

Abstract: Bicyclic dihydropyrimidine-carboxamide compounds of formula I described herein inhibit Rho Kinase and may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), and pulmonary arterial hypertension (PAH).

公开(公告)号：US20180215758A1

公开(公告)日：2018-08-02

申请号：US15883729

申请日：2018-01-30

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Alessandro Accetta ,  Fabio Rancati ,  Anna Maria Capelli ,  David Edward Clark ,  Patrizia Tisselli ,  Christine Edwards ,  Gurdip Bhalay ,  Arnaud Jean Francois Auguste Cheguillaume

IPC: C07D471/04 ,  C07D498/04 ,  C07D471/08 ,  A61K31/437 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/5383 ,  A61K31/4375 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/444 ,  A61K31/439 ,  A61K31/501 ,  A61K31/498 ,  A61K9/00

Abstract: Bicyclic dihydropyrimidine-carboxamide compounds of formula I described herein inhibit Rho Kinase and may be used for the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).

公开(公告)号：US10954236B2

公开(公告)日：2021-03-23

申请号：US16656842

申请日：2019-10-18

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Alessandro Accetta ,  Fabio Rancati ,  Anna Maria Capelli ,  David Edward Clark ,  Patrizia Tisselli ,  Christine Edwards ,  Gurdip Bhalay ,  Arnaud Jean Francois Auguste Cheguillaume

IPC: A61P11/00 ,  C07D471/04 ,  C07D519/00 ,  C07D487/04 ,  A61K9/00 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/439 ,  A61K31/444 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/498 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/5383 ,  C07D471/08 ,  C07D498/04

Abstract: Bicyclic dihydropyrimidine-carboxamide compounds of formula I described herein inhibit Rho Kinase and may be used for the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).

公开(公告)号：US10584128B2

公开(公告)日：2020-03-10

申请号：US15850720

申请日：2017-12-21

Applicant: CHIESI FARMACEUTICI S.p.A.

Inventor： Alessandro Accetta ,  Fabio Rancati ,  Anna Maria Capelli ,  David Edward Clark ,  Patrizia Tisselli ,  Christine Edwards ,  Gurdip Bhalay

IPC: A61K31/519 ,  C07D487/04 ,  A61P11/06 ,  A61K9/00 ,  A61K45/06 ,  A61P11/00 ,  A61P37/00

Abstract: Bicyclic dihydropyrimidine-carboxamide compounds of formula I described herein inhibit Rho Kinase and may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), and pulmonary arterial hypertension (PAH).