A mechanism is described for facilitating smart spill/fill data transfers in computing environments. A method of embodiments, as described herein, includes facilitating dividing a kernel into regions including low pressure regions and high pressure regions, where the low pressure regions are associated with low use of registers hosted by a processor of a computing device, while the high pressure regions are associated with high use of the registers. The method may further include transferring of data between memory and the registers based on at least one of the low pressure regions and the high pressure regions.