A brake release device and a robot manipulator employing the same are provided. The robot manipulator includes a housing and a brake element. The housing defines an inner space and has an opening, and the inner space is in communication with a space outside the housing through the opening. The brake element is disposed within the inner space. The robot manipulator stops or is allowed to actuate according to a position of the brake element. The brake release device is connected with the brake element. The brake release device is partially located in the inner space, and the brake release device partially penetrates through the opening and is exposed from the housing. When the part of the brake release device exposed from the housing is moved by an external force so as to drive the brake element to move synchronously, the robot manipulator is allowed to actuate.