- 专利标题: Diamino-alkylamino-linked arylsulfonamide compounds with selective activity in voltage-gated sodium channels
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申请号: US16345913申请日: 2017-11-13
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公开(公告)号: US10968210B2公开(公告)日: 2021-04-06
- 发明人: Thomas J. Greshock , James Mulhearn , Anthony J. Roecker , Tianying Jian , Gang Zhou , Liangqin Guo , Walter Won , Ting Zhang , Rajan Anand , John E. Stelmach , Deping Wang , Ronald M. Kim , Mark E. Layton , Christopher S. Burgey , Philippe G. Nantermet
- 申请人: Merck Sharp & Dohme Corp. , Thomas J. Greshock , James Mulhearn , Anthony J. Roecker , Tianying Jian , Gang Zhou , Liangqin Guo , Walter Won , Ting Zhang , Rajan Anand , John E. Stelmach , Deping Wang , Ronald M. Kim , Mark E. Layton , Christopher S. Burgey , Philippe G. Nantermet
- 申请人地址: US NJ Rahway; US PA Collegeville; US PA North Wales; US PA West Point; US NJ Westfield; US NJ Bridgewater; US NJ Edison; US CA San Carlos; US NJ Princeton Junction; US NJ Fanwood; US NJ Westfield; US PA Furlong; US NJ Summit; US PA Harleysville; US PA Philadelphia; US PA North Wales
- 专利权人: Merck Sharp & Dohme Corp.,Thomas J. Greshock,James Mulhearn,Anthony J. Roecker,Tianying Jian,Gang Zhou,Liangqin Guo,Walter Won,Ting Zhang,Rajan Anand,John E. Stelmach,Deping Wang,Ronald M. Kim,Mark E. Layton,Christopher S. Burgey,Philippe G. Nantermet
- 当前专利权人: Merck Sharp & Dohme Corp.,Thomas J. Greshock,James Mulhearn,Anthony J. Roecker,Tianying Jian,Gang Zhou,Liangqin Guo,Walter Won,Ting Zhang,Rajan Anand,John E. Stelmach,Deping Wang,Ronald M. Kim,Mark E. Layton,Christopher S. Burgey,Philippe G. Nantermet
- 当前专利权人地址: US NJ Rahway; US PA Collegeville; US PA North Wales; US PA West Point; US NJ Westfield; US NJ Bridgewater; US NJ Edison; US CA San Carlos; US NJ Princeton Junction; US NJ Fanwood; US NJ Westfield; US PA Furlong; US NJ Summit; US PA Harleysville; US PA Philadelphia; US PA North Wales
- 代理商 Sylvia A. Ayler; Catherine D. Fitch
- 国际申请: PCT/US2017/061221 WO 20171113
- 国际公布: WO2018/093694 WO 20180524
- 主分类号: C07D417/12
- IPC分类号: C07D417/12 ; C07D417/14 ; C07D277/52 ; C07D471/04 ; C07D487/10 ; C07D401/12 ; C07D471/08 ; C07D471/10 ; C07D487/04 ; C07D487/08
摘要:
Disclosed are compounds of Formula A, or a salt thereof: Formula (A), wherein: Het, Q and R1A to R4A are defined herein, which compounds have properties for blocking Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A or their salts, and methods of treating cough, itch, acute pain and neuropathic pain disorders using the same.
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