Pre-moistened wipes that include one or more characteristics correlated to desired properties, such as high durability, mileage, cleaning composition retention, efficacy, or the like are described. Pulp substrates typically include an anionic charge, which can result in binding or retention of a cationic biocide such as a quaternary ammonium compound while the remainder of the composition is released from the wipe (e.g., through squeezing, wiping or other compression). The present wipes are specifically tailored to include a pore size distribution characterized by pores having a size from 300 μm to 400 μm, which is larger than the pore distribution characteristics of existing wipes. Such characteristics increase release of a quaternary ammonium compound to a target surface, providing improved microefficacy, without the need for any cationic biocide release agents such as latex or a cationic salt.