- 专利标题: Microparticle production process and apparatus
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申请号: US15780211申请日: 2016-12-16
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公开(公告)号: US10981131B2公开(公告)日: 2021-04-20
- 发明人: Paul Seaman , Huw Jones , Liam McAleer
- 申请人: MIDATECH PHARMA (WALES) LIMITED
- 申请人地址: GB Cardiff South Glamorgan
- 专利权人: MIDATECH PHARMA (WALES) LIMITED
- 当前专利权人: MIDATECH PHARMA (WALES) LIMITED
- 当前专利权人地址: GB Cardiff South Glamorgan
- 代理机构: Bozicevic, Field & Francis LLP
- 代理商 Rudy J. Ng; Carol L. Francis
- 优先权: GB1522423 20151218
- 国际申请: PCT/EP2016/081436 WO 20161216
- 国际公布: WO2017/103113 WO 20170622
- 主分类号: B01J2/08
- IPC分类号: B01J2/08 ; B01J2/04 ; B01J2/18
摘要:
Provided is an apparatus for producing solid polymeric microparticles, the apparatus comprising a plurality of liquid droplet generators for forming liquid droplets of a first liquid, and a nozzle for forming a jet of a second liquid, wherein the plurality of liquid droplet generators and the nozzle are arranged relative to each other such that, in use, liquid droplets from the plurality of liquid droplet generators pass through a gas into said jet of second liquid. Also provided is a process for producing solid microparticles, the process comprising: providing a first liquid comprising a solute and a solvent, the solute comprising a biocompatible polymer, the concentration of polymer in the first liquid being at least 10% w/v, ‘w’ being the weight of the polymer and ‘v’ being the volume of the solvent, providing a plurality of liquid droplet generators operable to generate liquid droplets, providing a jet of a second liquid, causing the plurality of liquid droplet generators to form liquid droplets of the first liquid, passing the liquid droplets through a gas to contact the jet of the second liquid so as to cause the solvent to exit the droplets, thus forming solid microparticles, the solubility of the solvent in the second liquid being at least 5 g of solvent per 100 ml of second liquid, the solvent being substantially miscible with the second liquid.
公开/授权文献
- US20190193037A1 MICROPARTICLE PRODUCTION PROCESS AND APPARATUS 公开/授权日:2019-06-27