Invention Grant
- Patent Title: Prins reaction and intermediates useful in the synthesis of halichondrin macrolides and analogs thereof
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Application No.: US16313196Application Date: 2017-06-30
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Publication No.: US10981929B2Publication Date: 2021-04-20
- Inventor: Charles E. Chase , Hyeong-Wook Choi , Atsushi Endo , Francis G. Fang , Dae-Shik Kim
- Applicant: EISAI R&D MANAGEMENT CO., LTD.
- Applicant Address: JP Tokyo
- Assignee: EISAI R&D MANAGEMENT CO., LTD.
- Current Assignee: EISAI R&D MANAGEMENT CO., LTD.
- Current Assignee Address: JP Tokyo
- Agency: Clark & Elbing LLP
- International Application: PCT/US2017/040401 WO 20170630
- International Announcement: WO2018/006031 WO 20180104
- Main IPC: C07D493/22
- IPC: C07D493/22
Abstract:
The invention provides methods for the synthesis of a halichondrin macrolides or analogs thereof through a cyclization reaction strategy. The strategy of the present invention involves subjecting an intermediate to Prins reaction conditions to afford a macrolide. The invention also provides compounds useful as intermediates in the synthesis of a halichondrin macrolides or analogs thereof and methods for preparing the same.
Public/Granted literature
- US11136335B2 Prins reaction and intermediates useful in the synthesis of halichondrin macrolides and analogs thereof Public/Granted day:2021-10-05
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