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公开(公告)号：US10717743B2
公开(公告)日：2020-07-21
申请号：US16284405
申请日：2019-02-25
发明人： Charles E. Chase , Atsushi Endo , Francis G. Fang , Jing Li
IPC分类号： C07D493/20 , C07D307/28 , C07D307/33 , C07D493/08 , C07D493/18 , C07D493/04 , C07D493/22 , C07D307/20 , C07D307/26 , C07D309/16 , C07D405/06 , C07D405/14
摘要： Methods of synthesizing intermediates useful for the synthesis of halichondrin B analogs are described.
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公开(公告)号：US20190100513A1
公开(公告)日：2019-04-04
申请号：US15529798
申请日：2016-11-17
发明人： Gregg F. Keaney , John Wang , Baudouin Gerard , Kenzo Arai , Xiang Liu , Guo Zhu Zheng , Kazunobu Kira , Parcharee Tivitmahaisoon , Sudeep Prajapati , Nicholas C. Gearhart , Yoshihiko Kotake , Satoshi Nagao , Regina Mikie Kanada Sonobe , Masayuki Miyano , Norio Murai , Silvia Buonamici , Lihua Yu , Eunice Sun Park , Betty Chan , Peter G. Smith , Michael P. Thomas , Ermira Pazolli , Kian Huat Lim , Atsushi Endo , Arani Chanda
IPC分类号： C07D405/14 , A61P35/02
摘要： The present disclosure provides a novel solid state form of pladienolide pyridine compounds, compositions comprising at least one such solid state form, and methods of preparation and use and the same. The novel solid state form of pladienolide pyridine compounds may be useful in the treatment of cancer, such as, for example, cancers in which agents that target the spliceosome and mutations therein are known to be useful.
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公开(公告)号：US20180273532A1
公开(公告)日：2018-09-27
申请号：US15841767
申请日：2017-12-14
发明人： Roch Boivin , Eric Carlson , Atsushi Endo , Hans Hansen , Lynn D. Hawkins , Sally Ishizaka , Matthew Mackey , Sridhar Narayan , Takashi Satoh , Shawn Schiller
IPC分类号： C07D471/04 , A61K31/55 , C07D487/04 , A61K31/519
CPC分类号： C07D471/04 , A61K31/519 , A61K31/55 , C07D487/04 , Y02P20/582
摘要： Embodiments of the disclosure relate to tetrahydropyrazolopyrimidine compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis.
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公开(公告)号：US09856276B2
公开(公告)日：2018-01-02
申请号：US15196600
申请日：2016-06-29
发明人： Atsushi Endo , Charles E. Chase , Francis G. Fang
IPC分类号： C07D307/12 , C07F7/18 , C07D405/06 , C07D405/12 , C07D493/04 , C07D407/06 , C07D307/38
CPC分类号： C07F7/1804 , C07D307/12 , C07D307/38 , C07D405/06 , C07D405/12 , C07D407/06 , C07D493/04 , Y02P20/55
摘要： In general, the invention features compounds useful for the synthesis of analogs of halichondrin B, such as eribulin or pharmaceutically acceptable salts thereof, e.g., eribulin mesylate. Exemplary compounds are of formula (I), (II), or (III):
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公开(公告)号：US11926619B2
公开(公告)日：2024-03-12
申请号：US17045952
申请日：2019-04-08
发明人： Gregg F. Keaney , John Wang , Baudouin Gerard , Kenzo Arai , Xiang Liu , Guo Zhu Zheng , Kazunobu Kira , Lisa A. Marcaurelle , Marta Nevalainen , Ming-Hong Hao , Morgan Welzel O'Shea , Parcharee Tivitmahaisoon , Sudeep Prajapati , Tuoping Luo , Nicholas C. Gearhart , Jason T. Lowe , Yoshihiko Kotake , Satoshi Nagao , Regina Mikie Kanada Sonobe , Masayuki Miyano , Norio Murai , Andrew Cook , Shelby Ellery , Atsushi Endo , James Palacino , Dominic Reynolds
IPC分类号： C07D407/12 , A61K31/365 , A61K31/4427 , A61K31/497 , A61K45/06 , A61P35/00 , C07D313/00 , C07D405/12 , C07D405/14 , C07D407/06 , C07D407/14 , C07D413/12 , C07D417/12 , C07D487/08 , C07D487/10 , C07D491/107
CPC分类号： C07D407/06 , A61K45/06 , A61P35/00 , C07D313/00 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D487/08 , C07D487/10 , C07D491/107
摘要： The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.
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公开(公告)号：US20180354939A1
公开(公告)日：2018-12-13
申请号：US16108964
申请日：2018-08-22
发明人： J. Eric Carlson , Hans Hansen , Lynn Hawkins , Sally Ishizaka , Matthew Mackey , Shawn Schiller , Chikako Ogawa , Heather Davis , Atsushi Endo
IPC分类号： C07D417/14 , C07D403/14 , C07D413/04 , C07D401/10 , C07D401/14 , C07D471/10 , C07D487/10 , C07D471/04 , C07D215/48 , C12Q1/6897 , G01N33/50 , C07D451/04 , C07D487/04 , C07D493/10 , C07D413/14
CPC分类号： C07D417/14 , C07B2200/07 , C07D215/48 , C07D401/10 , C07D401/14 , C07D403/14 , C07D413/04 , C07D413/14 , C07D451/04 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/10 , C07D493/10 , C12Q1/6897 , G01N33/5023 , G01N33/5047
摘要： Embodiments of the disclosure relate to selectively substituted quinolone compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis.
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公开(公告)号：US09850242B2
公开(公告)日：2017-12-26
申请号：US15233520
申请日：2016-08-10
发明人： Roch Boivin , Eric Carlson , Atsushi Endo , Hans Hansen , Lynn D. Hawkins , Sally Ishizaka , Matthew Mackey , Sridhar Narayan , Takashi Satoh , Shawn Schiller
IPC分类号： A01N43/90 , A61K31/519 , C07D471/04 , C07D487/04 , A61K31/55
CPC分类号： C07D471/04 , A61K31/519 , A61K31/55 , C07D487/04 , Y02P20/582
摘要： Embodiments of the disclosure relate to tetrahydropyrazolopyrimidine compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis.
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公开(公告)号：US20160339032A1
公开(公告)日：2016-11-24
申请号：US15233520
申请日：2016-08-10
发明人： Roch Boivin , Eric Carlson , Atsushi Endo , Hans Hansen , Lynn D. Hawkins , Sally Ishizaka , Matthew Mackey , Sridhar Narayan , Takashi Satoh , Shawn Schiller
IPC分类号： A61K31/519 , A61K31/55
CPC分类号： C07D471/04 , A61K31/519 , A61K31/55 , C07D487/04 , Y02P20/582
摘要： Embodiments of the disclosure relate to tetrahydropyrazolopyrimidine compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis
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公开(公告)号：US09446046B2
公开(公告)日：2016-09-20
申请号：US14806174
申请日：2015-07-22
发明人： Roch Boivin , Eric Carlson , Atsushi Endo , Hans Hansen , Lynn D. Hawkins , Sally Ishizaka , Matthew Mackey , Sridhar Narayan , Takashi Satoh , Shawn Schiller
IPC分类号： A01N43/90 , A61K31/519 , C07D471/04 , C07D487/04
CPC分类号： C07D471/04 , A61K31/519 , A61K31/55 , C07D487/04 , Y02P20/582
摘要： Embodiments of the disclosure relate to tetrahydropyrazolopyrimidine compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis.
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公开(公告)号：US09382262B2
公开(公告)日：2016-07-05
申请号：US14577417
申请日：2014-12-19
发明人： Atsushi Endo , Charles E. Chase , Francis G. Fang
IPC分类号： C07D407/06 , C07D493/04 , C07D405/06 , C07D405/12 , C07D307/38
CPC分类号： C07F7/1804 , C07D307/12 , C07D307/38 , C07D405/06 , C07D405/12 , C07D407/06 , C07D493/04 , Y02P20/55
摘要： In general, the invention features compounds useful for the synthesis of analogs of halichondrin B, such as eribulin or pharmaceutically acceptable salts thereof, e.g., eribulin mesylate. Exemplary compounds are of formula (I), (II), or (III):
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