A packet forwarding method, device, and system for use in non-volatile memory express (NVMe) over fabric are described. According to the method, a first packet sent by a control device is received; a second packet is generated according to the first packet; a network port for forwarding the second packet is selected according to an identity of a target non-volatile memory; and the second packet is encapsulated into a packet that meets an NVMe over fabric forwarding requirement, and the encapsulated second packet is sent by using the selected network port.