An interactive sign language response (ISLR) system and method are described herein. The method includes receiving, by the interactive sign language response system, a video call from a videophone used by a video calling party, the video call including a video signal between the videophone and the interactive sign language response system; sending, by the interactive sign language response system and by way of the video call, a video prompt to be displayed on the videophone of the video calling party; and detecting, by the interactive sign language response system and by way of the video call, a response from the video calling party to the video prompt. In at least one embodiment, the interactive sign language recognition system performs automatic sign language recognition to determine one or more gestures in the video signal.